Investigation of risk factors for mortality in aged guide dogs: A retrospective cohort study
Investigation of risk factors for mortality in aged guide dogs: A retrospective cohort study
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DOI：
10.1016/j.prevetmed.2016.09.002
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发表时间：
2016-09-15
影响因子：
2.6
通讯作者：
Desquilbet, L.
中科院分区：
文献类型：
--
作者：
Hoummady, S.;Hua, J.;Desquilbet, L.
据估计，家犬的总体中位寿命为9-12年，但对老年和先验健康犬的死亡风险因素知之甚少。这项回顾性队列研究的目的是确定哪些特征与老年和先验健康导盲犬的死亡率相关，在一项对116只导盲犬的回顾性队列研究中，这些导盲犬在8-10岁时进行了系统的老年医学检查。老年网格收集临床数据，并在检查时测量常规生物学参数。单变量（Kaplan-Meier估计）和多变量（考克斯比例风险模型）生存分析用于评估与全因死亡时间的相关性。大多数犬是金毛猎犬（n =48）和拉布拉多猎犬（n = 27）。老年检查时的中位年龄为8.9岁。在随访期间，共有76只狗死亡，导致老年医学检查的中位生存时间为4.4年。校正人口统计学和生物学变量后，丙氨酸氨基转移酶水平升高（校正的风险比（校正的HR），6.2; 95%置信区间[95%CI]，2.0-19.0; P
The overall median lifespan of domestic dogs has been estimated to 9-12 years, but little is known about risk factors for mortality in aged and a priori healthy dogs.The objective of this retrospective cohort study was to determine which characteristics are associated with mortality in aged and a priori healthy guide dogs, in a retrospective cohort study of 116 guide dogs followed from a systematic geriatric examination at the age of 8-10 years old. A geriatric grid collected the clinical data and usual biological parameters were measured at the time of examination. Univariate (Kaplan-Meier estimates) and multivariable (Cox proportional hazard model) survival analyses were used to assess the associations with time to all-cause death.The majority of dogs were Golden Retrievers (n =48) and Labrador Retrievers (n = 27). Median age at geriatric examination was 8.9 years. A total of 76 dogs died during follow-up, leading to a median survival time from geriatric examination of 4.4 years. After adjustment for demographic and biological variables, an increased alanine amionotransferase level (adjusted Hazard Ratio (adjusted HR), 6.2; 95% confidence interval [95%CI], 2.0-19.0; P