An Easy Access to 2-Substituted Azulenes from Azulene-2-boronic Acid Pinacol Ester
An Easy Access to 2-Substituted Azulenes from Azulene-2-boronic Acid Pinacol Ester
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DOI：
10.1055/s-0028-1083224
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发表时间：
2008-12-01
影响因子：
2.6
通讯作者：
Sugihara, Yoshikazu
中科院分区：
文献类型：
--
作者：
Fujinaga, Masayuki;Suetake, Kouichi;Sugihara, Yoshikazu
偶氮烯-2-硼酸蒎醇酯可以很方便地转化为含有羧基、甲酰、酯或氨基的2-取代偶氮烯，这是传统方法难以获得的。然后，将合成的2-阿苏烯羧酸进行Ugi四组分缩合，得到含有阿苏烯骨架的二肽型产物。
Azulene-2-boronic acid pinacol ester was conveniently transformed into 2-substituted azulenes bearing carboxyl, formyl, ester, or amino groups, which are difficult to access by conventional methods. Furthermore, the azulene-2-carboxylic acid thus synthesized was subjectcd to the Ugi four-component condensation to obtain a dipeptide-type product containing an azulene skeleton.