REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE
REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE
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DOI：
10.1016/0092-8674(94)90204-6
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发表时间：
1994-10-21
期刊：
影响因子：
64.5
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
AIBA, A;CHEN, C;TONEGAWA, S
我们产生了一种新的突变小鼠品系，其编码代谢型谷氨酸受体1（mGluR1）的基因缺失。突变小鼠海马的大体解剖、兴奋性突触传递、长时程抑制和海马CA1区的短时程增强均明显正常。与此相反，长时程增强（LTP）大大减少，并观察到一个中等程度的障碍，在特定的上下文联想学习。我们认为mGluR1在LTP的产生过程中并不“在线”，而是调节可塑性过程，从而影响特定于上下文的联想学习。
We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not ''in line'' in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.