Synthesis as an Expanding Resource in Human Milk Science.
Synthesis as an Expanding Resource in Human Milk Science.
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DOI：
10.1021/jacs.1c05599
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发表时间：
2021-07
影响因子：
15
通讯作者：
Lianyan L Xu;Steven D. Townsend
中科院分区：
文献类型：
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作者：
Lianyan L Xu;Steven D. Townsend
很少有天然产物能与寡糖的大胆结构相媲美。然而，它们的复杂性一直是转化研究的巨大障碍，因为从自然界获得同质材料是具有挑战性的。因此，虽然碳水化合物对生物科学的无数功能和结构方面至关重要，但它们的行为主要是描述性的。这一挑战为合成化学提供了一个有吸引力的机会，特别是在人乳科学领域。首先，存在对合成均质人乳低聚糖（HMO）的过度需求。叠加在这个目标上的是进行大规模合成以使动物研究成为可能的使命。在这里，我们提出了一个个性化的反思我们的参与，我们的同事，这导致了HMO和机械探针的合成和表征。沿着，我们强调化学，化学酶，合成生物学为基础的方法。最后，我们讨论了母乳科学中广泛定义的合成面临的挑战和机遇。
Few classes of natural products rival the structural audacity of oligosaccharides. Their complexity, however, has stood as an immense roadblock to translational research, as access to homogeneous material from nature is challenging. Thus, while carbohydrates are critical to the myriad functional and structural aspects of the biological sciences, their behavior is largely descriptive. This challenge presents an attractive opportunity for synthetic chemistry, particularly in the area of human milk science. First, there is an inordinate need for synthesizing homogeneous human milk oligosaccharides (HMOs). Superimposed on this goal is the mission of conducting syntheses at scale to enable animal studies. Herein, we present a personalized rumination of our involvement, and that of our colleagues, which has led to the synthesis and characterization of HMOs and mechanistic probes. Along the way, we highlight chemical, chemoenzymatic, and synthetic biology based approaches. We close with a discussion on emergent challenges and opportunities for synthesis, broadly defined, in human milk science.