Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
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DOI：
10.1194/jlr.p020909
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发表时间：
2012-05-01
影响因子：
6.5
通讯作者：
Tinahones, F. J.
中科院分区：
文献类型：
--
作者：
Clemente-Postigo, M.;Queipo-Ortuno, M. I.;Tinahones, F. J.
在肥胖中观察到的低度炎症与高脂肪饮食有关，尽管这种关系尚不完全清楚。肠道菌群产生的细菌内毒素可能是相关因素。然而，这在肥胖患者中尚未得到证实。为了研究高脂肪饮食与细菌内毒素之间的关系，我们分析了脂肪超载后病态肥胖患者餐后内毒素血症。本文测定了40例病态肥胖患者在基线和脂肪超载后3小时血清和乳糜微粒分数中的内毒素水平，并分析了内毒素水平与胰岛素抵抗程度和餐后高甘油三酯血症的关系。餐后高甘油三酯血症最高的病态肥胖患者在脂肪超载后血清脂多糖（LPS）水平和乳糜微粒分数显著升高。餐后乳糜微粒脂多糖水平与餐后甘油三酯和基线甘油三酯的差异呈正相关。c反应蛋白（CRP）与LPS水平无显著相关性。影响脂肪超载后血清LPS水平的主要变量是基线和餐后甘油三酯水平，而不是葡萄糖或胰岛素抵抗。此外，脂肪超载后超氧化物歧化酶活性显著降低。脂肪超载后餐后脂多糖增加与病态肥胖患者餐后高甘油三酯血症有关，但与胰岛素抵抗程度无关。-Clemente-Postigo， M. I. Queipo-Ortuno， M. Murri， M. Boto-Ordonez， P. Perez-Martinez， C. Andres-Lacueva， F. Cardona和F. J. Tinahones脂肪超载后内毒素增加与病态肥胖患者餐后高甘油三酯血症有关。[j] .油脂杂志。2012。53: 973 - 978。
The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, this has not been confirmed in obese patients. To study the relationship between a high-fat diet and bacterial endotoxin, we analyzed postprandial endotoxemia in morbidly obese patients after a fat overload. The endotoxin levels were determined in serum and the chylomicron fraction at baseline and 3 h after a fat overload in 40 morbidly obese patients and their levels related with the degree of insulin resistance and postprandial hypertriglyceridemia. The morbidly obese patients with the highest postprandial hypertriglyceridemia showed a significant increase in lipopolysaccharide (LPS) levels in serum and the chylomicron fraction after the fat overload. Postprandial chylomicron LPS levels correlated positively with the difference between postprandial triglycerides and baseline triglycerides. There were no significant correlations between C-reactive protein (CRP) and LPS levels. The main variables contributing to serum LPS levels after fat overload were baseline and postprandial triglyceride levels but not glucose or insulin resistance. Additionally, superoxide dismutase activity decreased significantly after the fat overload.jlr Postprandial LPS increase after a fat overload is related to postprandial hypertriglyceridemia but not to degree of insulin resistance in morbidly obese patients.-Clemente-Postigo, M., M. I. Queipo-Ortuno, M. Murri, M. Boto-Ordonez, P. Perez-Martinez, C. Andres-Lacueva, F. Cardona, and F. J. Tinahones. Endotoxin increase after fat overload is related to post prandial hypertriglyceridemia in morbidly obese patients. J. Lipid Res. 2012. 53: 973-978.