Antibodies cross-reactive with DNA and cardiolipin in patients with systemic lupus erythematosus.
Antibodies cross-reactive with DNA and cardiolipin in patients with systemic lupus erythematosus.
复制标题
系统性红斑狼疮患者体内的抗体与 DNA 和心磷脂发生交叉反应。
DOI：
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发表时间：
1982
影响因子：
4.6
通讯作者：
A. Kumagai
中科院分区：
文献类型：
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作者：
T. Koike;H. Tomioka;A. Kumagai
用改良的固相放射免疫分析法(RIA)分析了11例DNA结合活性高的系统性红斑狼疮(SLE)患者血清与磷脂的交叉反应能力。同时与ssDNA和dsDNA反应的多特异性抗DNA抗体能够与磷脂，特别是心磷脂发生交叉反应。还讨论了梅毒生物假阳性血清学试验(BFP-STS)与血清抗DNA抗体水平的关系。
Using a modified solid phase radioimmunoassay (RIA), sera from 11 patients with systemic lupus erythematosus (SLE) that had high DNA binding activities were analysed for their ability to cross-react with phospholipids. Polyspecific anti-DNA antibodies that reacted with both ssDNA and dsDNA had the ability to cross-react with phospholipids, especially cardiolipin. The relationship between biological false-positive serological tests for syphilis (BFP-STS) and the magnitude of serum anti-DNA antibody levels is also discussed.