Expressions of ABCG2, CD133, and podoplanin in salivary adenoid cystic carcinoma.
Expressions of ABCG2, CD133, and podoplanin in salivary adenoid cystic carcinoma.
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DOI：
10.1155/2014/132349
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发表时间：
2014
影响因子：
--
通讯作者：
Nagatsuka H
中科院分区：
文献类型：
--
作者：
Li W;Tamamura R;Wang B;Liu Q;Liu H;Liu T;Katase N;Xiao J;Nagatsuka H
腺样囊性癌是涎腺最常见的恶性肿瘤之一，具有较高的复发和转移风险。目前对癌症干细胞（CSCs）的研究已经证实，CSCs是肿瘤发生和发展的驱动力，这表明可以通过有效地靶向和杀死CSCs来建立新的癌症治疗方法。本研究的主要目的是通过免疫组织化学分析来研究ABCG 2、CD 133和podoplanin在小涎腺ACC中的表达模式。我们发现ABCG 2在正常的唾液腺组织中弱表达。ACC中ABCG 2表达显著上调，Ki-67表达模式相似。结果表明：正常组织和ACC中CD 133和podoplanin的表达均为阳性，但在正常组织和ACC中CD 133和podoplanin的表达无显著性差异，提示CSC可能存在于ABCG 2阳性的静止细胞中，ACC中的CSCs被ABCG 2和Ki-67阳性表达的细胞所包围，ABCG 2和Ki-67共染色有助于预测CSCs的定位。
Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.
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影响因子：
12.4
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
3.7
作者：
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影响因子：
11.2
作者：
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影响因子：
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作者：
Chiou, Shih-Hwa;Yu, Cheng-Chia;Lo, Jeng-Fan
通讯作者：
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