Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial
Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial
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DOI：
10.3945/ajcn.112.037184
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发表时间：
2012-12-01
影响因子：
7.1
通讯作者：
Zeisel, Steven H.
中科院分区：
文献类型：
--
作者：
Cheatham, Carol L.;Goldman, Barbara Davis;Zeisel, Steven H.
背景：胆碱对胎儿大脑发育至关重要，目前尚不清楚典型的美国饮食中是否含有足够的胆碱以确保大脑的最佳发育。目的：本研究旨在确定补充卵磷脂(胆碱的主要饮食来源)是否能改善其子女的认知能力。设计：在一项双盲随机对照试验中，140名孕妇被随机分配到补充卵磷脂(750 Me)或安慰剂(玉米油)，从妊娠18周到产后90天。在婴儿出生10个月和12个月时，对99名婴儿进行短期视觉空间记忆、长期情景记忆、语言发展和全球发展测试。结果：被研究的妇女饮食中胆碱的摄入量接近360 mg/d(与孕妇推荐摄入量的80%，哺乳期妇女推荐摄入量的65%相似)。磷脂酰胆碱补充剂耐受性良好。在全球发展、语言发展、短期视觉空间记忆或长期情景记忆方面，两组没有显著差异。结论：孕妇补充磷脂酰胆碱并不能增强婴儿的大脑功能。更长的跟踪期可能会揭示出后发制人的影响。此外，未来的研究应该确定，补充母亲吃的胆碱含量低得多的饮食，比如几个低收入国家的饮食，是否会促进婴儿的大脑发育。这项试验在Clinicaltrials.gov上注册为NCT00678925。AM J Clin Nutr 2012；96：1465-72。
Background: Choline is essential for fetal brain development, and it is not known whether a typical American diet contains enough choline to ensure optimal brain development.Objective: The study was undertaken to determine whether supplementing pregnant women with phosphatidylcholine (the main dietary source of choline) improves the cognitive abilities of their offspring.Design: In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholine (750 me) or a placebo (corn oil) from 18 wk gestation through 90 d postpartum. Their infants (n = 99) were tested for short-term visuospatial memory, long-term episodic memory, language development, and global development at 10 and 12 mo of age.Results: The women studied ate diets that delivered similar to 360 mg choline/d in foods (similar to 80% of the recommended intake for pregnant women, 65% of the recommended intake for lactating women). The phosphatidylcholine supplements were well tolerated. Groups did not differ significantly in global development, language development, short-term visuospatial memory, or long-term episodic memory.Conclusions: Phosphatidylcholine supplementation of pregnant women eating diets containing moderate amounts of choline did not enhance their infants' brain function. It is possible that a longer follow-up period would reveal late-emerging effects. Moreover, future studies should determine whether supplementing mothers eating diets much lower in choline content, such as those consumed in several low-income countries, would enhance infant brain development. This trial was registered at clinicaltrials.gov as NCT00678925. Am J Clin Nutr 2012;96:1465-72.