BRAIN-ADRENAL AXIS HORMONES ARE ALTERED IN THE CSF OF INFANTS WITH MASSIVE INFANTILE SPASMS
BRAIN-ADRENAL AXIS HORMONES ARE ALTERED IN THE CSF OF INFANTS WITH MASSIVE INFANTILE SPASMS
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DOI：
10.1212/wnl.42.6.1171
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发表时间：
1992-06-01
期刊：
影响因子：
9.9
通讯作者：
SAITO, M
中科院分区：
文献类型：
--
作者：
BARAM, TZ;MITCHELL, WG;SAITO, M
大规模婴儿痉挛症（MIS）是婴儿特有的癫痫发作疾病，被认为是未成熟大脑对各种侮辱和压力的年龄依赖性反应。ACTH和糖皮质激素是脑-肾上腺轴的主要成分，可改善癫痫发作。我们假设这些激素的中枢神经系统水平在MIS婴儿中是异常的，并通过分析促肾上腺皮质激素释放激素（CRH）、ACTH、皮质醇和白细胞介素-1-β研究了14名MIS婴儿和13名年龄匹配的对照婴儿的CSF。患者脑脊液ACTH水平明显低于对照组，但皮质醇水平差异无统计学意义。两组CRH水平相似，且每日波动。这些结果表明MIS中脑-肾上腺轴的特定CNS成分的改变。
Massive infantile spasms (MIS), a seizure disorder unique to infants, is considered an age-dependent response of the immature brain to various insults and stressors. The seizures improve with ACTH and glucocorticoids, both major components of the brain-adrenal axis. We hypothesized that CNS levels of these hormones are abnormal in infants with MIS and studied CSF from 14 infants with MIS and 13 age-matched controls by analysis for corticotropin-releasing hormone (CRH), ACTH, cortisol, and interleukin-1-beta. ACTH levels in CSF of patients were significantly lower than those of controls, but differences in cortisol levels between patients and controls were not statistically significant. CRH levels in both groups were similar and fluctuated diurnally. These results indicate an alteration of specific CNS components of the brain-adrenal axis in MIS.