MARKERS OF CARTILAGE MATRIX METABOLISM IN HUMAN JOINT FLUID AND SERUM - THE EFFECT OF EXERCISE
MARKERS OF CARTILAGE MATRIX METABOLISM IN HUMAN JOINT FLUID AND SERUM - THE EFFECT OF EXERCISE
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DOI：
10.1016/s1063-4584(05)80033-0
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发表时间：
1995-03-01
影响因子：
7
通讯作者：
LOHMANDER, LS
中科院分区：
文献类型：
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作者：
ROOS, H;DAHLBERG, L;LOHMANDER, LS
测量 33 名健康运动员运动前后膝关节液中软骨蛋白聚糖（聚集蛋白聚糖）、基质溶素-1、金属蛋白酶组织抑制剂-1（TIMP-1）和前胶原 II C 前肽的浓度，以及血清中聚集蛋白聚糖、透明质酸和硫酸角质素的水平。运动前的样本是在跑步或足球休息24小时后获取的，运动后的样本是在运动后30-60分钟获取的。 9 名运动员在跑步机上跑了 60 分钟，16 名运动员在公路上跑了 80 分钟，8 名运动员参加了一场足球比赛（90 分钟）。参考组由 28 名患有膝盖疼痛但没有关节病理或损伤证据的患者组成，用于进行比较。在关节液中，软骨基质降解过程中的单一标记物并未因运动而发生显着变化，但均呈上升趋势。与参考组相比，运动员休息时除溶基质素外的所有标记物的浓度均较低。在运动前跑步者的血清中，硫酸角质素的浓度显着高于足球组和参考组，并且在运动后进一步增加。运动后标记物的增加可能反映了机械负荷的影响以及这些个体中身体软骨基质可能的高周转率。
The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative processes in cartilage matrix changed significantly with exercise but all showed a rising trend. All markers except stromelysin showed lower concentrations in athletes at rest compared to the reference group. In serum from runners before exercise the concentration of keratan sulfate was significantly higher than in both the soccer and reference groups and further increased after exercise. The increase in markers after exercise may reflect an effect of mechanical loading in combination with a possible high turnover rate of body cartilage matrix in these individuals.