Incontinence induces stratum corneum vulnerability and impairs the skin barrier function in the perianal region
Incontinence induces stratum corneum vulnerability and impairs the skin barrier function in the perianal region
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DOI：
10.1159/000096192
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发表时间：
2006-01-01
期刊：
影响因子：
3.4
通讯作者：
Konya, Chizuko
中科院分区：
文献类型：
--
作者：
Nakagami, Gojiro;Sanada, Hiromi;Konya, Chizuko
背景：胰岛素导致皮肤屏障功能降低，同时也增加了皮肤破裂的风险。目的：探讨老年人肛门失禁患者肛周皮肤屏障功能的变化。研究方法：我们通过调查皮肤水合作用、皮肤pH值、神经酰胺的量以及对有和无失禁的患者的肛周区域进行皮肤病学皮肤检查来比较皮肤屏障功能。结果如下：21例失禁患者（70.0%）显示皮肤有光泽，这表明皮肤屏障受损，而在氟替卡松组中没有患者出现这种情况。在失禁组中，那些有光泽的皮肤显示出显着更大的皮肤pH值和神经酰胺总量比那些正常的皮肤（p = 0.0099，p = 0.0179，分别）。结论：这些结果表明，有光泽的皮肤可能是一个有用的指标，减少肛周皮肤屏障功能。版权所有（c）2006 S. Karger AG，巴塞尔。
Background: Incontinence leads to a reduced skin barrier function, while also increasing the risk of skin breakdown. Aim: To investigate the perianal skin barrier function of elderly patients with or without incontinence. Methods: We compared the skin barrier function by investigating the skin hydration, the skin pH, the amount of ceramide and by making a dermatological skin inspection of the perianal region in patients with and without incontinence. Results: Twenty-one incontinent patients (70.0%) showed a glossy skin, which indicates impairment of the skin barrier while none of the patients in the continence group did so. In the incontinence group, those who had a glossy skin showed a significantly greater skin pH and total amount of ceramide than those with a normal skin (p = 0.0099, p = 0.0179, respectively). Conclusions: These results demonstrate that a glossy skin may be a useful indicator of a reduced perianal skin barrier function. Copyright (c) 2006 S. Karger AG, Basel.