Low-Fat Dietary Pattern Intervention and Health-Related Quality of Life: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
Low-Fat Dietary Pattern Intervention and Health-Related Quality of Life: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
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DOI：
10.1016/j.jand.2015.07.016
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发表时间：
2016-02-01
影响因子：
4.8
通讯作者：
Wenger, Nanette
中科院分区：
文献类型：
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作者：
Assaf, Annlouise R.;Beresford, Shirley A. A.;Wenger, Nanette
背景强化饮食干预计划可能会带来活力和健康质量的其他组成部分的好处。女性健康倡议饮食调整(DM)干预包括一项大规模的强化干预的随机对照试验。目的评估干预是否与改善健康相关生活质量(HRQL)子量表、总体自我报告健康、抑郁症状、认知功能和睡眠质量有关。设计这项随机对照试验被分析为意向治疗。在1993至1998年间，美国40个临床中心招募了48,835名50岁至79岁的女性。符合条件的包括脂肪摄入量在基线=总卡路里的32%，并排除了有任何结直肠癌或乳腺癌、最近其他癌症、1型糖尿病或有预计生存的医疗条件的女性。
Background Intensive dietary intervention programs may lead to benefits in vitality and other components of health quality. The Women's Health Initiative Dietary Modification (DM) intervention includes a large randomized controlled trial of an intensive intervention.Objective To evaluate whether the intervention is associated with improved health-related quality of life (HRQoL) subscales, overall self-reported health, depression symptoms, cognitive functioning, and sleep quality.Design This randomized controlled trial was analyzed as intent to treat.Participants Between 1993 and 1998, 48,835 women aged 50 to 79 years were recruited by 40 clinical centers across the United States. Eligibility included having fat intake at baseline >= 32% of total calories, and excluded women with any prior colorectal or breast cancer, recent other cancers, type 1 diabetes, or medical conditions with predicted survival