Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice
Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice
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DOI：
10.1016/j.vaccine.2005.02.035
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发表时间：
2005-09-23
期刊：
影响因子：
5.5
通讯作者：
Kawabata, S
中科院分区：
文献类型：
--
作者：
Okamoto, S;Tamura, Y;Kawabata, S
链球菌免疫球蛋白（Ig）结合蛋白Sib35与人、小鼠和牛的IgG、IgM和IgA结合。由于所有检测的A组化脓性链球菌（GAS）菌株都表达sib35基因，我们评估了sib35作为GAS感染的候选疫苗。我们检测到GAS感染患者血清中抗sib35 IgG抗体滴度明显高于健康志愿者。用Sib35诱导小鼠血清中抗原特异性IgG抗体和兔Sib35特异性抗血清免疫小鼠，均表现出抑制活性。Sib35免疫提高了GAS毒株攻击小鼠的存活率，同时对宿主没有毒性。我们得出结论，Sib35是一种很有希望预防GAS感染的疫苗。(c) 2005 Elsevier Ltd版权所有。
The streptococcal immunoglobulin (Ig)-binding protein Sib35 binds to IgG, IgM and IgA in human, mouse and bovine. Since all group A Streptococcus pyogenes (GAS) strains examined express the sib35 gene, we evaluated the Sib35 as a vaccine candidate against GAS infections. We detected significantly higher anti-Sib35 IgG antibody titers in sera from patients with GAS infections than from healthy volunteers. Immunization of mice with Sib35 induced antigen-specific IgG antibodies in their sera, and rabbit Sib35-specific antiserum showed opsonic activity. Immunization with Sib35 enhanced survival rates in mice challenged with a GAS strain, while exhibiting no toxicity in hosts. We conclude that Sib35 is a promising vaccine for prevention of GAS infections. (c) 2005 Elsevier Ltd. All rights reserved.