PROCESSING OF COLLOIDAL GOLD PARTICLES IN THE GLOMERULAR MESANGIUM AND MACULA DENSA OF THE DUCK KIDNEY
PROCESSING OF COLLOIDAL GOLD PARTICLES IN THE GLOMERULAR MESANGIUM AND MACULA DENSA OF THE DUCK KIDNEY
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DOI：
10.1016/0040-8166(88)90030-4
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发表时间：
1988-01-01
期刊：
影响因子：
2.6
通讯作者：
SPLECHTNA, H
中科院分区：
文献类型：
--
作者：
DITRICH, H;SPLECHTNA, H
将牛血清白蛋白包被的胶体金颗粒静脉注射到健康成年家鸭体内。用透射电子显微镜观察这些示踪剂颗粒在肾小球系膜血管中的去向，时间序列长达4.5天。大量的颗粒聚集体被困在系膜通道系统中，被系膜细胞吞噬，排出到系膜通道，经细胞外转运至血管门，再被致密斑细胞再次吞噬，排入肾小管腔。在所选的实验模型中，这一过程需要大约19个小时，尽管即使在给药4-5天后，这个过程也会继续进行，程度要低得多。这种大分子排泄模式可能与几种形式的肾炎的发病机制有关。
Bovine-serum-albumin coated colloidal gold particles were injected intravenously into healthy, adult domestic ducks. The fate of these tracer particles was followed in a time-sequence up to 4.5 days in the renal glomerular mesangium.sbd.distal tubule macula densa junction with transmission electron microscopy. The bulk of particle aggregates is ''trapped'' in the mesangial channel system, phagocyted by mesangial cells, exocyted back into the mesangial channels, transported extracellularily towards the vasular hilus, rephagocyted by macula densa cells and expelled into the tubular lumen. This process requires about nineteen hours in the experimental model chosen, although it continues to take place to a much lower extent even 4-5 days after administration of the tracer. This mode of macromolecular excretion may be of interest in connection with the pathogenesis of several forms of glomerulonephritis.