Integrated Serologic Surveillance of Population Immunity and Disease Transmission
Integrated Serologic Surveillance of Population Immunity and Disease Transmission
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DOI：
10.3201/eid2407.171928
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发表时间：
2018-07-01
影响因子：
11.8
通讯作者：
Lammie, Patrick J.
中科院分区：
文献类型：
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作者：
Arnold, Benjamin F.;Scobie, Heather M.;Lammie, Patrick J.
抗体在生物标志物中是独一无二的，因为它们能够识别对疫苗可预防疾病具有保护性免疫力的人，并能够测量过去接触不同病原体的情况。大多数传染病监测仍以单一疾病为重点，但利用多重抗体检测对现有血清学调查进行更广泛的测试将为综合监测创造新的机会。从这个角度来看，我们强调了多个潜在协同领域，其中综合监测可以比当前通过垂直项目进行独立疾病监测的趋势为公共卫生工作增加更多价值。我们描述了实验室和数据科学领域的创新，这些创新应加速整合并确定标本采集、测试和分析方面剩余的挑战。在整个过程中，我们说明了通过综合监测平台生成的信息如何能够创造新的机会，以更快、更准确地识别全球卫生计划的差距，这些差距包括疫苗接种不足、新出现的病原体以及涵盖多种传染病的多层次健康差距。
Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus, but broader testing of existing serologic surveys with multiplex antibody assays would create new opportunities for integrated surveillance. In this perspective, we highlight multiple areas for potential synergy where integrated surveillance could add more value to public health efforts than the current trend of independent disease monitoring through vertical programs. We describe innovations in laboratory and data science that should accelerate integration and identify remaining challenges with respect to specimen collection, testing, and analysis. Throughout, we illustrate how information generated through integrated surveillance platforms can create new opportunities to more quickly and precisely identify global health program gaps that range from undervaccination to emerging pathogens to multilayered health disparities that span diverse communicable diseases.