Redox signalling involving NADPH oxidase-derived reactive oxygen species
Redox signalling involving NADPH oxidase-derived reactive oxygen species
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DOI：
10.1042/bst0340960
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发表时间：
2006-11-01
影响因子：
3.9
通讯作者：
Shah, A. M.
中科院分区：
文献类型：
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作者：
Dworakowski, R.;Anilkumar, N.;Shah, A. M.
氧化应激的增加在动脉粥样硬化、糖尿病、心肌梗死和心力衰竭等多种疾病的病理生理中起着重要作用。除了众所周知的氧自由基的破坏作用外，ROS（活性氧）还具有信号传导作用，作为第二信使调节多种细胞内信号通路和转录因子的活性，从而诱导细胞表型的变化。NADPH氧化酶似乎是参与氧化还原信号的ROS的特别重要来源。七种NADPH氧化酶异构体，被称为Noxs （NAPDH氧化酶），以细胞和组织特异性的方式表达。这些氧化酶被认为具有不同的功能，因为它们的激活受到严格调节（例如，受神经激素、生长因子和机械刺激），并与不同的下游信号通路特异性耦合。在本文中，我们回顾了NADPH氧化酶的结构和激活机制，并考虑它们在氧化还原信号的参与，主要集中在心血管系统。
increased oxidative stress plays an important role in the pathophysiology of many diseases such as atherosclerosis, diabetes mellitus, myocardial infarction and heart failure. in addition to the well-known damaging effects of oxygen-free radicals, ROS (reactive oxygen species) also have signalling roles, acting as second messengers that modulate the activity of diverse intracellular signalling pathways and transcription factors, thereby inducing changes in cell phenotype. NADPH oxidases appear to be especially important sources of ROS involved in redox signalling. Seven NADPH oxidase isoforms, known as Noxs (NAPDH oxidases), are expressed in a cell- and tissue-specific fashion. These oxidases are thought to subserve distinct functions as a result of their tightly regulated activation (e.g. by neurohormonal and growth factors and mechanical stimuli) and their specific coupling with distinct downstream signalling pathways. In the present paper, we review the structure and mechanisms of activation of NADPH oxidases and consider their involvement in redox signalling, focusing mainly on the cardiovascular system.