Nasal Cancer in the Northamptonshire Boot and Shoe Industry
Nasal Cancer in the Northamptonshire Boot and Shoe Industry
复制标题
北安普敦郡靴子和制鞋业的鼻癌
DOI：
10.1136/bmj.1.5693.385
复制
发表时间：
1970
影响因子：
--
通讯作者：
B. Jolles
中科院分区：
文献类型：
--
作者：
E. Acheson;R. Cowdell;B. Jolles
报告了1953年至1967年期间北安普顿郡鼻癌发病率的调查。在15年间确诊的46例鼻癌患者中，有21例（男19例，女2例）曾在靴子和鞋业工作过。在1953年之前或1967年之后在北安普顿郡从事靴子和鞋业工作的人员中诊断的其他五个病例是从各种来源确定的。北安普敦郡男性靴子和鞋子操作员的鼻癌发病率（综合考虑所有组织学类型）明显高于癌症登记区选择进行比较的所有职业类别的男性和在北安普敦郡其他职业工作的男性。最近，在北安普顿郡的靴子和鞋业中，每年有1至2例新病例。北安普顿郡工业的病例几乎全部发生在相对较少的工人身上，他们暴露在制造鞋类所用材料的粉尘中。这个行业可能有两种致癌因素——一种与鼻腺癌的产生有关，另一种与鼻腔和鼻窦的鳞状癌和可能的其他类型的癌有关。这需要进一步研究。我们对腺癌病例的最佳潜伏期估计为54.6年，比鳞状、移行和间变性肿瘤患者的潜伏期（41.7年）长得多。我们没有证据来回答这个问题，即这些事实是否仍然存在于工业环境中，尽管毫无疑问，自这些人第一次暴露以来，工业的卫生标准已经大大提高了。鞋履修理行业可能会增加患鼻腺癌的风险，但这需要进一步的研究。我们的证据表明，吸鼻烟应该被认为是工业和非工业鼻癌的一个可能的促成因素。关于呼吸道癌症，建议对鞋类制造和修理行业进行调查。应进一步努力尽量减少灰尘的吸入。应该考虑鞋类行业鼻癌处方的案例。
A survey of the incidence of nasal cancer in Northamptonshire during the period 1953 to 1967 is reported. Of the 46 patients with nasal cancer ascertained during the 15-year period 21 (19 males and 2 females) had been employed at some time in the boot and shoe industry. Five other cases diagnosed either before 1953 or after 1967 in persons who had worked in the boot and shoe industry in Northamptonshire were ascertained from various sources. The incidence of nasal cancer (all histological types considered together) was significantly higher in male boot and shoe operatives in Northamptonshire than in males of all occupational classes in the Cancer Register areas selected for comparison and in males working in other occupations in Northamptonshire. The excess incidence has recently given rise to the occurrence of between 1 and 2 new cases per annum in the Northamptonshire boot and shoe industry. The cases within the Northamptonshire industry occurred almost entirely in the relatively small number of workers who are exposed to the dust of the materials used in the manufacture of footwear. Possibly there are two carcinogenic factors in the industry—one related to the production of nasal adenocarcinoma, and the other to squamous and possibly other types of carcinoma in the nasal cavity and sinuses. This requires further study. Our best estimate of the latent period for the adenocarcinoma cases was 54·6 years, which is substantially longer than for the patients with squamous, transitional, and anaplastic tumours (41·7 years). We have no evidence to answer the question whether the facts are still present in the industrial environment, though undoubtedly the standards of hygiene in the industry has improved substantially since these men were first exposed. There is probably an increased risk of nasal adenocarcinoma in the footwear repairing industry, but this requires further study. Our evidence suggests that snuff taking should be considered as a possible contributory factor in both industrial and non-industrial nasal cancer. A survey of the footwear manufacturing and repairing industry is recommended regarding cancer of the respiratory tract. Further attempts should be made to minimize the inhalation of dust. The case for the prescription of nasal cancer in the footwear industry should be considered.