Drug delivery of the future: Chasing the invisible gorilla.
Drug delivery of the future: Chasing the invisible gorilla.
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DOI：
10.1016/j.jconrel.2015.10.048
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发表时间：
2016-10-28
期刊：
影响因子：
--
通讯作者：
Park K
中科院分区：
文献类型：
--
作者：
Park K
60多年来，药物输送系统已经产生了大量的控释制剂，帮助患者提高依从性并最大限度地提高药物疗效。在1950-1980年期间，新的受控药物输送系统的发展卓有成效。以临床使用的配方数量衡量的生产率在1980-2010年间显著下降。需要了解这种生产率下降的情况，以便未来药物输送系统的发展能够加快和再次多产。这需要对目前的药物输送领域进行严格的评估，以便能够识别和解决阻碍快速进展的因素。目前的药物输送领域面临着一种看不见的大猩猩综合症，即当大猩猩不存在时看到它，而当它实际存在时却错过了它。克服这种综合症需要一种新的思维方式，质疑现状。药物输送技术的进步是一个进化过程，因此，试验和错误越多，进步就越快。药物输送领域需要培育一种环境，在那里可以测试截然不同的想法，所有数据，无论是积极的还是消极的，都需要自由交换，因为它们具有同等的重要性。
For more than 60 years drug delivery systems have produced numerous controlled release formulations helping patients improve compliance and maximize the drug efficacy. Development of new controlled drug delivery systems was very productive during the period 1950-1980. The productivity, as measured by the number of clinically used formulations, dropped significantly during 1980-2010. This reduced productivity needs to be understood so that the future development of drug delivery systems can be accelerated and prolific again. This requires critical evaluation of the current drug delivery field, so that the factors inhibiting rapid progress can be identified and resolved. The current drug delivery field is faced with an invisible gorilla syndrome, i.e., seeing a gorilla when it is not present and missing a gorilla when it actually exists. Overcoming this syndrome requires a new way of thinking, questioning the status quo. Advances in drug delivery technologies occur by an evolutionary process, and thus, the more trials and errors lead to faster advances. The drug delivery area needs to nurture the environment where vastly different ideas can be tested, and all data, positive or negative, need to be exchanged freely as they have equal importance.