The time has come to target connective tissue growth factor in diabetic complications
The time has come to target connective tissue growth factor in diabetic complications
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DOI：
10.1007/s00125-004-1423-6
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发表时间：
2004-05
期刊：
影响因子：
8.2
通讯作者：
Stephen M. Twigg;Mark E. Cooper
中科院分区：
文献类型：
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作者：
Stephen M. Twigg;Mark E. Cooper
这导致了CTGF促进早期系膜基质扩张和晚期糖尿病肾病中纤维化的后期变化的假设[10]。ECM扩张是受糖尿病影响的组织中的常见特征。事实上，我们最近发现CTGF在非肾组织中也增加。CTGF的增加与啮齿动物糖尿病性心肌病中心肌III型胶原的病理性增加相对应[11]。在动脉粥样硬化的糖尿病apoE缺陷小鼠模型中，CTGF mRNA和蛋白质水平在纤维帽的复杂病变中增加，其中还观察到ECM的增加[12]。在糖尿病啮齿动物的眼睛中，CTGF在视网膜的神经节细胞层中上调[13]。这些数据表明，CTGF可能有助于糖尿病微血管和大血管并发症，糖尿病微血管并发症的主要代谢途径导致CTGF表达增加。根据细胞类型，升高的细胞外葡萄糖、活性氧、与糖尿病有关的其他生长因子，例如TGF-β和血管内皮生长因子（VEGF）[14]，
leading to the hypothesis that CTGF contributes to early mesangial matrix expansion and the later changes of fibrosis in advanced diabetic nephropathy [10]. ECM expansion is a common feature in tissue affected by diabetes. Indeed, we have recently shown that CTGF is also increased in non-renal tissue. The increases in CTGF correspond with pathological increases in myocardial type III collagen in rodent diabetic cardiomyopathy [11]. In the diabetic apoE-deficient mouse model of atheroma, CTGF mRNA and protein levels are increased in the complex lesions at the fibrous caps, where increases in ECM are also observed [12]. In the eye of the diabetic rodent, CTGF is up-regulated in the ganglion cell layer of the retina [13]. These data suggest that CTGF may contribute to microvascular and macrovascular complications in diabetes.The main metabolic pathways implicated in microvascular complications in diabetes cause an increase in CTGF expression. Depending on the cell type, elevated extracellular glucose, reactive oxygen species, other growth factors implicated in diabetes, eg TGF-β and vascular endothelial growth factor (VEGF)[14],