A multiunit model of solute and water removal by inner medullary vasa recta
A multiunit model of solute and water removal by inner medullary vasa recta
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DOI：
10.1152/ajpheart.1998.274.4.h1202
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发表时间：
1998-04-01
影响因子：
4.8
通讯作者：
Pallone, TL
中科院分区：
文献类型：
--
作者：
Edwards, A;Pallone, TL
最近的一个模型的体积和溶质的微循环交换在肾髓质的基础上，一个单一的降血管直肠（DVR）进行了扩展，占不同数量的血管沿着皮髓质轴。在容积摄取过程中，升直血管（AVR）壁的浓度极化消除了跨壁压差的假设进行了检查。在这种限制性情况下，如果球囊中的压力超过AVR管腔中的压力，则小的流体静压梯度可以驱动AVR容积摄取。计算出的跨AVR的液压差产生的预测值和测量值之间的AVR-DVR血液流速比的协议被认为是小于报告的最大压差AVR可以维持。模拟还证实了以前的结论，表明DVR中尿素转运蛋白的存在抵消了水通道的存在，否则水通道会降低肾髓质中小溶质捕获的效率。
A recent model of volume and solute microcirculatory exchange in the renal medulla based on a single descending vasa rectum (DVR) was extended to account for the varying number of vessels along the corticomedullary axis. The assumption that concentration polarization at the walls of ascending vasa recta (AVR) during volume uptake eliminates transmural oncotic pressure gradients was examined. In this limiting case, small hydrostatic pressure gradients can drive AVR volume uptake if the pressure in the interstitium exceeds that in the AVR lumen. The calculated hydraulic pressure difference across AVR yielding agreement between predicted and measured values of AVR-to-DVR blood flow rate ratios was found to be smaller than the reported maximum pressure difference AVR can sustain. Simulations also confirmed previous conclusions suggesting that the presence of urea transporters in DVR counterbalances that of water channels that would otherwise decrease the efficiency of small solute trapping in the renal medulla.