Robustness of the p53 network and biological hackers
Robustness of the p53 network and biological hackers
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DOI：
10.1016/j.febslet.2005.03.101
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发表时间：
2005-06-06
期刊：
影响因子：
3.5
通讯作者：
Papageorgiou, LG
中科院分区：
文献类型：
--
作者：
Dartnell, L;Simeonidis, E;Papageorgiou, LG
p53蛋白相互作用网络在调节后生动物细胞周期和凋亡中起着至关重要的作用。本文通过分析p53网络在两种攻击模式下的退化，研究了其鲁棒性。线性规划用于计算蛋白质之间的平均路径长度和网络直径作为功能的度量。研究发现，p53网络对于随机丢失的节点是稳健的，但由于其结构的原因，它的中枢容易受到有针对性的攻击。这些结果的意义是考虑到蛋白质的突变敲除和肿瘤诱导病毒的定向攻击。(c) 2005年欧洲生化学会联合会。Elsevier B.V.版权所有。
The p53 protein interaction network is crucial in regulating the metazoan cell cycle and apoptosis. Here, the robustness of the p53 network is studied by analyzing its degeneration under two modes of attack. Linear Programming is used to calculate average path lengths among proteins and the network diameter as measures of functionality. The p53 network is found to be robust to random loss of nodes, but vulnerable to a targeted attack against its hubs, as a result of its architecture. The significance of the results is considered with respect to mutational knockouts of proteins and the directed attacks mounted by tumour inducing viruses. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.