CALCITONIN GENE-RELATED PEPTIDE AND CEREBRAL BLOOD-VESSELS - DISTRIBUTION AND VASOMOTOR EFFECTS
CALCITONIN GENE-RELATED PEPTIDE AND CEREBRAL BLOOD-VESSELS - DISTRIBUTION AND VASOMOTOR EFFECTS
复制标题
DOI：
10.1038/jcbfm.1987.126
复制
发表时间：
1987-12-01
影响因子：
6.3
通讯作者：
UDDMAN, R
中科院分区：
文献类型：
--
作者：
EDVINSSON, L;EKMAN, R;UDDMAN, R
含有降钙素基因相关肽（CGRP）的神经纤维对脑血管的神经支配和这种肽的血管舒缩作用被描述为许多不同的哺乳动物物种。cgrp免疫反应性神经纤维存在于所有动物（豚鼠、猪、猫、兔、大鼠和小鼠）的脑动脉外膜中。在所有物种的三叉神经节中均可见大量含有CGRP免疫反应性的核周。在大脑血管周围神经纤维和三叉神经核周围，CGRP常与P物质和神经激肽a共定位。CGRP免疫反应神经纤维的密度和放射线免疫测定的脑血管水平均存在明显的种间差异。豚鼠脑血管中浓度最高，兔脑血管中浓度最低，猫和人脑血管中浓度居中。CGRP在所有研究物种（人类脑动脉、猫脑中动脉、兔子、豚鼠和大鼠基底动脉）中都是一种有效的脑动脉扩张剂。引起半最大反应的CGRP浓度范围从0.4 nM（人头动脉）到3 nM（大鼠和家兔基底动脉）。用低浓度的P物质（0.1 nM）或神经动素A （3 nM）预处理脑动脉，可轻微减弱cgrp诱导的豚鼠基底动脉弛豫。从人和豚鼠身上发现降钙素是一种非常弱的脑动脉扩张剂。因此，含有CGRP的心血管神经纤维似乎存在于所有哺乳动物物种中（尽管程度不同），CGRP对所有物种来说都是一种有效的脑动脉扩张剂。
The innervation of cerebral blood vessels by nerve fibers containing calcitonin gene-related peptide (CGRP) and the vasomotor effects of this peptide are described for a number of different mammalian species. CGRP-immunoreactive nerve fibers were present in the adventitia of cerebral arteries in all species examined (guinea, pig, cat, rabbit, rat, and mouse). Numerous perikarya containng CGRP immunoreactivity are demonstrable in the trigeminal ganglion of all species. In the cerebral perivascular nerve fibers and in trigeminal perikarya, CGRP is often colocalized with substance P and neurokinin A. Marked interpsecies differences exist both in the density of CGRP-immunoreactive nerve fibers and in the cerebrovascular levels measured with radioimmunoassay. The highest concentrations were observed in cerebral vessels from guinea pigs, the lowest concentration in rabbit vessels, and intermediate levels in the feline and human cerebral vasculature. CGRP is a potent dilator of cerebral arteries in all species examined (human pial, feline middle cerebral, rabbit, guinea pig and rat basilar arteries). The concentration of CGRP eliciting half-maximal responses ranged from 0.4 nM (human pial artery) to 3 nM (rat and rabbit basilar arteries). Pretreatment of cerebral arteries with low concentrations of either cerebral arteries with low concentrations of either substance P (0.1 nM) or neurokinin A (3 nM) attenuated slightly the CGRP-induced relaxations of guinea pig basilar arteries. Calcitonin was found to be a very weak dilator of cerebral arteries from human and guinea pig. Thus, cardiovascular nerve fibers containing CGRP appear to be present in all mammalian species (although to varying degrees) and CGRP is invariably a potent dilator of the cerebral arteries for all species.