Coordinated Functional Divergence of Genes after Genome Duplication in Arabidopsis thaliana
Coordinated Functional Divergence of Genes after Genome Duplication in Arabidopsis thaliana
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DOI：
10.1105/tpc.17.00531
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发表时间：
2017-11-01
期刊：
影响因子：
11.6
通讯作者：
Van de Peer, Yves
中科院分区：
文献类型：
--
作者：
De Smet, Riet;Sabaghian, Ehsan;Van de Peer, Yves
在开花植物的进化过程中，基因和基因组的复制一直很猖獗。与小规模基因复制不同，全基因组复制（WGD）复制整个途径或网络，并因此产生独特的情况，其中这种复制的途径或网络可以通过其组成基因的协调子功能化或新功能化来进化新功能。在这里，我们描述了一个显着的情况下，协调基因表达分歧以下WGD在拟南芥。我们鉴定了一组92个同源基因对，它们在WGD后都显示出相似的组织特异性基因表达趋异模式，其中一个同源基因在气生组织中显示出主要表达，另一个同源基因在尖端生长组织中显示出偏向性表达。我们提供的证据表明，这种模式的基因表达分歧似乎涉及基因的作用，细胞极性和可能的功能，在维护细胞壁的完整性。在WGD之后，这些重复基因中的许多通过在生长/发育和应激反应中的亚功能化而进化出单独的功能。通过基因组复制将这些过程解偶联可能提供关于生长和形态发生以及防御生物和非生物胁迫的重要适应。
Gene and genome duplications have been rampant during the evolution of flowering plants. Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy entire pathways or networks, and as such create the unique situation in which such duplicated pathways or networks could evolve novel functionality through the coordinated sub-or neofunctionalization of its constituent genes. Here, we describe a remarkable case of coordinated gene expression divergence following WGDs in Arabidopsis thaliana. We identified a set of 92 homoeologous gene pairs that all show a similar pattern of tissue-specific gene expression divergence following WGD, with one homoeolog showing predominant expression in aerial tissues and the other homoeolog showing biased expression in tip-growth tissues. We provide evidence that this pattern of gene expression divergence seems to involve genes with a role in cell polarity and that likely function in the maintenance of cell wall integrity. Following WGD, many of these duplicated genes evolved separate functions through subfunctionalization in growth/development and stress response. Uncoupling these processes through genome duplications likely provided important adaptations with respect to growth and morphogenesis and defense against biotic and abiotic stress.