A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence
A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence
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DOI：
10.1111/j.1360-0443.2004.00707.x
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发表时间：
2004-06-01
期刊：
影响因子：
6
通讯作者：
Zweben, J
中科院分区：
文献类型：
--
作者：
Rawson, RA;Marinelli-Casey, P;Zweben, J
药物滥用治疗中心（CSAT）甲基苯丙胺治疗项目（MTP）是迄今为止最大的甲基苯丙胺（MA）依赖治疗随机临床试验。该研究的目的是比较矩阵模型，一种手动治疗方法，与治疗照常（TAU）在8个社区门诊设置在美国西部。设计超过18个月期间，1999年和2001年，978治疗寻求，MA依赖者被随机分配接受TAU或手动16周治疗（矩阵模型）.设置该研究作为一个八个地点的门诊试验进行，其中六个地点位于加州，蒙大拿和夏威夷各一个.结果在整个样本中，在大多数地点，那些被分配到矩阵治疗参加更多的临床会议，与分配接受TAU的受试者相比，接受治疗的时间更长，在治疗期间提供了更多的无MA尿液样本，并且MA戒断时间更长。药物的使用和功能的措施，收集在治疗出院和6个月后入院表明显着改善参与者在所有网站和条件相比，基线水平，但矩阵方法的优越性并没有坚持在这两个timepoint.Conclusions研究结果表明，一个显着的初步步骤，记录矩阵方法的疗效。虽然矩阵方法优于TAU的优势在治疗后时间点没有得到维持，但治疗中获益是对这种心理社会治疗方法的经验支持的重要证明。
Aims The Center for Substance Abuse Treatment (CSAT) Methamphetamine Treatment Project (MTP) is the largest randomized clinical trial of treatments for methamphetamine (MA) dependence to date. The objective of the study was to compare the Matrix Model, a manualized treatment method, with treatment-as-usual (TAU) in eight community out-patient settings in the Western United States.Design Over an 18-month period between 1999 and 2001, 978 treatment-seeking, MA-dependent people were randomly assigned to receive either TAU at each site or a manualized 16-week treatment (Matrix Model).Setting The study was conducted as an eight-site out-patient trial, with six sites located in California and one each in Montana and Hawaii.Findings In the overall sample, and in the majority of sites, those who were assigned to Matrix treatment attended more clinical sessions, stayed in treatment longer, provided more MA-free urine samples during the treatment period and had longer periods of MA abstinence than those assigned to receive TAU. Measures of drug use and functioning collected at treatment discharge and 6 months post-admission indicate significant improvement by participants in all sites and conditions when compared to baseline levels, but the superiority of the Matrix approach did not persist at these two timepoints.Conclusions Study results demonstrate a significant initial step in documenting the efficacy of the Matrix approach. Although the superiority of the Matrix approach over TAU was not maintained at the post-treatment timepoints, the in-treatment benefit is an important demonstration of empirical support for this psychosocial treatment approach.