Functioning and evolutionary significance of nutrient transceptors.
Functioning and evolutionary significance of nutrient transceptors.
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DOI：
10.1093/molbev/msp168
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发表时间：
2009-11
影响因子：
10.7
通讯作者：
J. Thevelein;K. Voordeckers
中科院分区：
文献类型：
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作者：
J. Thevelein;K. Voordeckers
营养转运体是一种具有受体功能的类似转运体的蛋白质，它的发现表明，化学信号的受体可能是从营养转运体进化而来的。现在有几个例子是具有额外的营养信号功能的营养转运体，具有类似转运体的序列和结构但没有运输能力的营养受体，以及以营养为配体的G蛋白偶联受体(GPCRs)。最近的研究结果表明，受体信号传递需要特定的配体诱导的构象变化，这表明受体的功能与常规受体相似。先进的生物信息学分析用于检测远缘相关蛋白的同源性，确定非转运葡萄糖转运蛋白Rgt2是酵母中与葡萄糖敏感的GPCRGpr1最接近的同源物。这支持了营养转运体在进化中的中间地位，介于营养转运体和化学信号的经典受体之间。
The discovery of nutrient transceptors, transporter-like proteins with a receptor function, suggests that receptors for chemical signals may have been derived in evolution from nutrient transporters. Several examples are now available of nutrient transporters with an additional nutrient signaling function, nutrient receptors with a transporter-like sequence and structure but without transport capacity, and G protein-coupled receptors (GPCRs) that have nutrients as ligands. Recent results have revealed that transceptor signaling requires a specific ligand-induced conformational change, which indicates that transceptors function in a similar way as regular receptors. Advanced bioinformatic analysis for detection of homology in distantly related proteins identifies the nontransporting glucose transceptor Rgt2 as the closest homologue of the glucose-sensing GPCR Gpr1 in yeast. This supports an intermediate position for nutrient transceptors in evolution, between nutrient transporters and classical receptors for chemical signals.