Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.
Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.
复制标题
使用非侵入性成像技术通过热疗进行脂质体药物输送的原理和测量。
DOI：
10.1080/02656730701840147
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Viglianti,BenjaminL
中科院分区：
文献类型：
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作者：
Tashjian,JessicaA;Dewhirst,MarkW;Needham,David;Viglianti,BenjaminL
本综述的目的是概述用于跟踪热疗期间或之后从脂质体制剂到肿瘤的药物递送的最先进的成像方式。脂质体是一种药物递送系统，由围绕水性核心的磷脂双层组成，并已被证明在热疗后会积聚。使用含有对比剂的脂质体与热疗相结合，有望直接测量药物剂量浓度，并通过 MR 和 PET/SPECT 成像方式非侵入性地描述药物分布模式。我们将回顾使用这种方法的基本原理以及在治疗期间和治疗后提供此类信息的潜在优势。
The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.