Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation
Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation
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DOI：
10.1021/acscatal.8b00440
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发表时间：
2018-03
期刊：
影响因子：
12.9
通讯作者：
Takayuki Wakaki;Takaya Togo;Daisuke Yoshidome;Y. Kuninobu;M. Kanai
中科院分区：
文献类型：
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作者：
Takayuki Wakaki;Takaya Togo;Daisuke Yoshidome;Y. Kuninobu;M. Kanai
我们开发了一种钯催化的C-H转化，使醛和(杂)芳基卤化物能够合成酮。吡啶甲酰胺配体的使用是实现转化的关键。利用该反应，以很好到很好的产率合成了杂芳基酮和二芳基酮，即使是克级的。密度泛函理论(DFT)计算结果支持C-H键活化途径。
We developed a palladium-catalyzed C–H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C–H bond activation pathway.