Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes
Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes
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DOI：
10.1016/j.peptides.2015.07.018
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发表时间：
2015-09-01
期刊：
影响因子：
3
通讯作者：
Peng, Yongde
中科院分区：
文献类型：
--
作者：
Gu, Liping;Ma, Yuhang;Peng, Yongde
Spexin mRNA和蛋白在大鼠组织中广泛表达，与饮食诱导的肥胖啮齿动物的体重减轻有关。它的位置在内分泌和上皮细胞也已提出。Spexin是一种新的肽，在饮食诱导的肥胖的啮齿动物中涉及体重减轻。因此，我们的目的是检查其在人体组织中的表达，并测试spexin是否可以在2型糖尿病（T2 DM）的葡萄糖和脂质代谢中发挥作用。spexin基因的表达和免疫反应性在肾上腺，皮肤，胃，小肠，肝脏，甲状腺，胰岛，内脏脂肪，肺，结肠和肾脏高于肌肉和结缔组织。T2 DM患者免疫反应性血清spexin水平降低，并与空腹血糖相关空腹血糖（FBG）、糖化血红蛋白（HbA 1c）、糖化血红蛋白（HbA 1c）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）的相关系数分别为-0.632、-0.236、-0.382，P < 0.001。口服葡萄糖耐量试验（OGTT）时，Spexin与血糖呈负相关。Spexin在正常人的内分泌和上皮组织中有强表达，表明Spexin可能参与内分泌和其他组织的生理功能。2型糖尿病患者循环spexin水平较低，与血糖和血脂呈负相关，提示该肽可能在2型糖尿病的糖脂代谢中发挥作用。(C)2015作者由爱思唯尔公司出版
Spexin mRNA and protein are widely expressed in rat tissues and associate with weight loss in rodents of diet-induced obesity. Its location in endocrine and epithelial cells has also been suggested. Spexin is a novel peptide that involves weight loss in rodents of diet-induced obesity. Therefore, we aimed to examine its expression in human tissues and test whether spexin could have a role in glucose and lipid metabolism in type 2 diabetes mellitus (T2DM). The expression of the spexin gene and immunoreactivity in the adrenal gland, skin, stomach, small intestine, liver, thyroid, pancreatic islets, visceral fat, lung, colon, and kidney was higher than that in the muscle and connective tissue. Immunoreactive serum spexin levels were reduced in T2DM patients and correlated with fasting blood glucose (FBG, r = -0.686, P < 0.001), hemoglobin A1c (HbA1c, r = -0.632, P < 0.001), triglyceride (TG, r = -0.236, P < 0.001) and low density lipoprotein-cholesterol (LDL-C, r = -0.382, P < 0.001). A negative correlation of blood glucose with spexin was observed during oral glucose tolerance test (OGTT). Spexin is intensely expressed in normal human endocrine and epithelial tissues, indicating that spexin may be involved in physiological functions of endocrine and in several other tissues. Circulating spexin levels are low in T2DM patients and negatively related to blood glucose and lipids suggesting that the peptide may play a role in glucose and lipid metabolism in T2DM. (C) 2015 The Authors. Published by Elsevier Inc.