Molecular and functional profiling of memory CD8 T cell differentiation
Molecular and functional profiling of memory CD8 T cell differentiation
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DOI：
10.1016/s0092-8674(02)01139-x
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发表时间：
2002-12-13
期刊：
影响因子：
64.5
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Kaech, SM;Hemby, S;Ahmed, R
记忆T细胞如何以及何时在免疫反应中形成是一个长期存在的问题。为了更好地理解记忆性CD8 T细胞发育，评估了病毒感染期间抗原特异性T细胞中基因表达和功能变化的时间过程。许多基因的表达在病毒清除后根据CD8 T细胞功能特性的变化而继续变化。尽管记忆细胞前体存在于免疫反应的高峰期，但这些细胞并没有显示出记忆T细胞的标志性功能特征。然而，这些细胞逐渐获得了自我更新和对抗原的快速回忆的记忆细胞性质，这表明抗原特异性CD8 T细胞在病毒感染后逐渐分化为记忆细胞的模型。
How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection.