COVID-19 Outcomes and Risk Factors Among People Living with HIV.
COVID-19 Outcomes and Risk Factors Among People Living with HIV.
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DOI：
10.1007/s11904-022-00618-w
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发表时间：
2022-10
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
在这篇综述中，我们研究了艾滋病毒和COVID-19流行病的交叉点，重点是COVID-19相关的健康结果和艾滋病毒感染者（PLWH）中SARS-CoV-2的风险因素。迄今为止的证据表明，与普通人群相比，PLWH中SARS-CoV-2感染的发生率并不高，尽管一旦暴露，PLWH发生严重COVID-19结果的风险更大。严重COVID-19的关键风险因素包括已知与严重疾病相关的非艾滋病毒合并症，以及艾滋病毒特异性风险因素，如低CD 4 + T细胞计数、未抑制的病毒载量和结核病合并感染。SARS-CoV-2大流行在黑人、拉丁裔和美洲原住民/阿拉斯加原住民PLWH中的不成比例的影响可能会加剧PLWH之间先前存在的健康结果差异。关于艾滋病毒感染者中SARS-CoV-2疫苗保护的数据需要进一步研究，尽管一些研究表明CD 4 + T细胞计数低的人的体液应答降低，而在两个大型观察队列中，艾滋病毒感染者的疫苗突破率增加。关于艾滋病毒感染者中SARS-CoV-2（PASC）急性后后遗症的数据也很有限。PLWH对SARS-CoV-2的易感性并不高，但一旦暴露，他们发生严重COVID-19后果的风险更高。需要投入额外资源，用于制定干预措施，以改善健康结果，并解决受COVID-19大流行影响的艾滋病毒携带者之间的差异。
In this review, we examine the intersection of the HIV and COVID-19 epidemics with focus on COVID-19-related health outcomes and risk factors for SARS-CoV-2 among people living with HIV (PLWH). Evidence to date do not suggest a higher incidence of SARS-CoV-2 infection among PLWH compared to the general population, although—once exposed—PLWH are at greater risk of severe COVID-19 outcomes. Key risk factors for severe COVID-19 include non-HIV comorbidities known to be associated with severe disease, as well as HIV-specific risk factors such as low CD4 + T-cell count, unsuppressed viral load, and tuberculosis co-infection. The disproportionate impact of the SARS-CoV-2 pandemic among Black, Latinx, and Native American/Alaskan Native PLWH could worsen pre-existing disparities in health outcomes among PLWH. Data on SARS-CoV-2 vaccine protection among PLWH needs additional study, although some studies suggest decreased humoral responses among those with low CD4 + T-cell counts, while there is a signal of increased vaccine breakthrough rates among PLWH in two large observational cohorts. Data on post-acute sequelae of SARS-CoV-2 (PASC) among PLWH is also limited. PLWH do not have a higher susceptibility to SARS-CoV-2, but once exposed, they are at higher risk of severe COVID-19 outcomes. Additional resources will need to be dedicated to the development of interventions to improve health outcomes and address disparities among PLWH impacted by the COVID-19 pandemic.
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影响因子：
6.7
作者：
Fromentin R;Bakeman W;Lawani MB;Khoury G;Hartogensis W;DaFonseca S;Killian M;Epling L;Hoh R;Sinclair E;Hecht FM;Bacchetti P;Deeks SG;Lewin SR;Sékaly RP;Chomont N
通讯作者：
Chomont N
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ
影响因子：
11.8
作者：
Dandachi, Dima;Geiger, Grant;Chow, Jeremy
通讯作者：
Chow, Jeremy
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G
影响因子：
3.8
作者：
Avelino-Silva, Vivian I.;Miyaji, Karina T.;Kallas, Esper G.
通讯作者：
Kallas, Esper G.