The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases.
The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases.
复制标题
哺乳动物阶段克氏锥虫的主要 85 kDa 表面抗原是唾液酸酶家族。
DOI：
10.1073/pnas.88.10.4481
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发表时间：
1991
影响因子：
11.1
通讯作者：
Eisen,H
中科院分区：
文献类型：
--
作者：
Kahn,S;Colbert,TG;Wallace,JC;Hoagland,NA;Eisen,H
克氏锥虫是一种感染多种脊椎动物的细胞内原生动物寄生虫，是导致人类恰加斯病的病原体。据估计，南美洲和中美洲有1500万至2000万人感染了这种寄生虫。恰加斯病通常导致严重的自身免疫和炎症病理，在流行地区是心力衰竭的主要原因。然而，人们对导致这种病理的宿主-寄生虫相互作用知之甚少。我们之前已经克隆了一个大基因家族(SA85-1)的几个成员，并证明这些基因编码85 kDa的弓形虫，哺乳动物阶段特有的表面抗原。在这里，我们报告了SA85-1家族的成员具有唾液酸酶活性，并被寄生虫脱落。我们认为唾液酸酶可能通过从免疫系统的细胞中分解唾液酸而在弓形虫感染的病理过程中起作用。
Trypanosoma cruzi, an intracellular protozoan parasite infecting a wide variety of vertebrates, is the agent responsible for Chagas disease in humans. An estimated 15-20 million people in South and Central America are infected with the parasite. Chagas disease often results in severe autoimmune and inflammatory pathology and is the major cause of heart failure in endemic areas. Nevertheless, little is known about the host-parasite interactions that lead to this pathology. We have previously cloned several members of a large gene family (SA85-1) and shown that these genes encode 85-kDa T. cruzi, mammalian-stage-specific, surface antigens. Here we report that members of the SA85-1 family possess sialidase activity and are shed by the parasite. We suggest that the sialidases may contribute to the pathology during T. cruzi infection by cleaving sialic acid from cells of the immune system.