COGNITIVE DEFICITS IN PATIENTS WITH SMALL-CELL LUNG-CANCER BEFORE AND AFTER CHEMOTHERAPY
COGNITIVE DEFICITS IN PATIENTS WITH SMALL-CELL LUNG-CANCER BEFORE AND AFTER CHEMOTHERAPY
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DOI：
10.1016/0169-5002(95)00446-8
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发表时间：
1995-06-01
期刊：
影响因子：
5.3
通讯作者：
KOMAKI, R
中科院分区：
文献类型：
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作者：
MEYERS, CA;BYRNE, KS;KOMAKI, R
我们对小细胞肺癌（SCLC）患者的认知功能进行了一项前瞻性研究。先前的一项研究表明，SCLC 患者在接受预防性颅脑照射 (PCI) 之前，记忆力、额叶执行功能和运动技能均存在缺陷。进行这项研究是为了确定这些缺陷是否与放化疗有关。我们评估了两组患者：一组是新诊断且未经治疗的患者，另一组是放化疗后且 PCI 之前。采用严格的资格标准来尽量减少任何可能影响认知功能的现有因素。结果显示，SCLC 患者在接受放化疗前存在认知缺陷，特别是在语言记忆、额叶执行功能和运动协调测试方面。在任何测试中，接受治疗和未接受治疗的患者之间没有差异。目前正在研究的病因学考虑包括副肿瘤现象。
We conducted a prospective study of cognitive function in patients with small cell lung cancer (SCLC). A previous study had shown SCLC patients to have deficits in memory, frontal lobe executive functioning, and motor skills before they received prophylactic cranial irradiation (PCI). This study was performed to determine whether these deficits were related to chemoradiation treatment. We evaluated two groups of patients: one newly diagnosed and untreated, the other post-chemoradiation and before PCI. Strict eligibility criteria were used to minimize any preexisting factors that might influence cognitive functioning. Results showed that patients with SCLC have cognitive deficits before receiving chemoradiation, specifically on tests of verbal memory, frontal lobe executive functions, and motor coordination. There was no difference between the treated and untreated patients on any test. Etiologic considerations currently under study include paraneoplastic phenomena.