c-Fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection
c-Fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection
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DOI：
10.1128/iai.01316-06
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发表时间：
2007-03-01
影响因子：
3.1
通讯作者：
Matsuo, Koichi
中科院分区：
文献类型：
--
作者：
Maruyama, Kenta;Sano, Gen-ichiro;Matsuo, Koichi
c-Fos是转录因子AP-1的组成部分。我们发现，缺乏c-Fos的巨噬细胞表现出促炎细胞因子的产生增强，增强NF-κ B磷酸化，并增加沙门氏菌感染后的细胞死亡。此外，缺乏c-Fos的小鼠对感染高度敏感，这表明c-Fos赋予小鼠对沙门氏菌感染的抗性。
c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappa B phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.