The expression of surface antigen Leu 1 by ocular adnexal lymphoid neoplasms.
The expression of surface antigen Leu 1 by ocular adnexal lymphoid neoplasms.
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眼附属器淋巴肿瘤表面抗原Leu 1的表达。
DOI：
10.1016/0002-9394(82)90082-4
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发表时间：
1982
影响因子：
4.2
通讯作者：
Wang,CY
中科院分区：
文献类型：
--
作者：
Knowles2nd,DM;Jakobiec,FA;Wang,CY
Leu1是一种表膜抗原，表达于良性系统T细胞，大多数为B细胞性慢性淋巴细胞白血病，约占全身性B细胞淋巴瘤的一半。良性系统B细胞为Leu1-。我们的研究表明，6例眼附属器假性淋巴瘤中Leu1+细胞与OKT3+E+(T)细胞的百分比基本相同，强烈提示这些病变中的良性B细胞类似于Leu1-。这些研究还表明，在15例眼B细胞淋巴瘤中，有6例(40%)恶性B细胞是Leu1+。因此，一些恶性眼球附件B细胞表达Leu1，而良性眼球附件B细胞不表达Leu1，这似乎与淋巴和其他系统B细胞的情况相似。尽管这一共同决定因素的存在原因尚不清楚，但Leu1的表达作为肿瘤B细胞的标志物可能具有临床和诊断意义
Leu 1 is a surface membrane antigen expressed by benign systemic T cells, most cases of B-cell-derived chronic lymphocytic leukemia, and approximately one half of the systemic B-cell lymphomas. Benign systemic B cells are Leu 1-. Our studies showed that the percentage of Leu 1+cells was essentially the same as the percentage of OKT3+E+(T) cells in six ocular adnexal pseudolymphomas, strongly suggesting that the benign B cells in these lesions were similarly Leu 1-. These studies also showed that malignant B cells in six of 15 (40%) ocular B-cell lymphomas were Leu 1+. Thus, the expression of Leu 1 by some malignant ocular adnexal B cells but not by benign ocular adnexal B cells appears to be analogous to the situation for lymph nodal and other systemic B cells. Although the explanation for the existence of this shared determinant is unknown, Leu 1 expression may possess clinical and diagnostic significance as a marker of neoplastic B cells