Epigenetic mechanisms as targets and companions of viral assaults
Epigenetic mechanisms as targets and companions of viral assaults
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DOI：
10.1111/j.1749-6632.2011.06357.x
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Ekstrom, Tomas J.
中科院分区：
文献类型：
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作者：
Ernberg, Ingemar;Karimi, Mohsen;Ekstrom, Tomas J.
过去十年，人们对了解表观遗传机制的兴趣激增。这并不奇怪，因为很明显我们需要这些知识来理解基础生物学，例如细胞分化、干细胞维持、病理表型、病因和治疗反应。同样明显的是，持续暴露在环境中会通过表观遗传机制影响我们的功能基因组。这篇简短的综述将提出表观遗传机制的一般原理，以及不断影响我们生理机能的病毒感染如何与这些机制相结合，以逃避宿主防御并促进其自身的增殖和/或潜伏期。
The past decade has seen an explosion of interest for understanding epigenetic mechanisms. This is not surprising since it has been obvious that we need this knowledge to understand basic biology, such as cellular differentiation, stem cell maintenance, and pathological phenotype, etiology, and therapy responses. It is also evident that the constant exposure to the environment affects our functional genomes through epigenetic mechanisms. This short review will bring up general principles of epigenetic mechanisms as well as how viral infections, which constantly affect our physiology, can interphase with these in order to evade host defense and promote their own multiplication and/or latency.