Effect of n-3 long chain polyunsaturated fatty acids during the perinatal period on later body composition
Effect of n-3 long chain polyunsaturated fatty acids during the perinatal period on later body composition
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DOI：
10.1017/s0007114512001511
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发表时间：
2012-06-01
影响因子：
3.6
通讯作者：
Moreno, L. A.
中科院分区：
文献类型：
--
作者：
Rodriguez, G.;Iglesia, I.;Moreno, L. A.
本研究系统回顾了有关孕期和产后摄入n-3长链多不饱和脂肪酸（LCPUFA）对婴幼儿身体成分影响的研究。在MEDLINE （PubMed）、EMBASE和LILACS数据库中执行结构化搜索策略。根据研究问题确定纳入标准和排除标准。无论研究设计如何，只有那些研究围产期n-3 LCPUFA暴露与后期肥胖（以体重、身高、体重指数（BMI）、皮褶厚度和/或周长衡量）之间的关系的研究被纳入研究。对研究质量进行评分，然后将其分类为孕妇在怀孕或哺乳期摄入n-3 LCPUFA的报告（6篇出版物）或婴儿摄入n-3 LCPUFA的报告（7篇出版物）。两项研究显示母亲n-3 LCPUFA摄入量与儿童后期身体组成（低脂肪、BMI或体重）呈负相关，两项研究显示直接相关，其余两项研究未观察到影响。在这些研究中，通过强化婴儿配方奶粉摄入n-3 LCPUFA；其中3只观察到对后期身体成分没有影响，2只随着n-3 LCPUFA量的增加而显示出更高的体重和肥胖。相反，在两项研究中，体重和脂肪量下降了。总之，报告的婴儿和幼儿的身体组成差异并不能清楚地解释围产期通过补充配方奶粉摄入n-3 LCPUFA、母乳喂养或母亲在怀孕和哺乳期间摄入n-3 LCPUFA。相关的操作机制，包括n-3 LCPUFA剂量和应用源没有得到充分解释，因此无法得出结论。
A systematic review to identify studies reporting the effects of n-3 long chain polyunsaturated fatty acids (LCPUFA) intake, during pregnancy and postnatally, on infants and young children's body composition was performed. A structured search strategy was performed in the MEDLINE (PubMed), EMBASE, and LILACS databases. Inclusion and exclusion criteria were defined according to the research question. Only those studies addressing the relationship between n-3 LCPUFA exposure during the perinatal period and later adiposity measured in terms of weight, height, body mass index (BMI), skinfold thickness and/or circumferences were included regardless of the study design. Studies quality was scored and were thereafter categorised into those reporting on maternal intake of n-3 LCPUFA during pregnancy or lactation (6 publications) or on infant's n-3 LCPUFA intake (7 publications). Two studies showed inverse associations between maternal n-3 LCPUFA intake and children's later body composition (lower adiposity, BMI or body weight), two showed direct associations and no effects were observed in the remaining two studies. Among those studies focusing on n-3 LCPUFA intake through enriched infant formulas; three observed no effect on later body composition and two showed higher weight and adiposity with increased amounts of n-3 LCPUFA. Reversely, in two studies weight and fat mass decreased. In conclusion, reported body composition differences in infants and young children were not clearly explained by perinatal n-3 LCPUFA intake via supplemented formulas, breastfeeding or maternal intakes of n-3 LCPUFA during pregnancy and lactation. Associated operational mechanisms including n-3 LCPUFA doses and sources applied are not sufficiently explained and therefore no conclusions could be made.