Long-range connectivity of mouse primary somatosensory barrel cortex
Long-range connectivity of mouse primary somatosensory barrel cortex
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DOI：
10.1111/j.1460-9568.2010.07264.x
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Petersen, Carl C. H.
中科院分区：
文献类型：
--
作者：
Aronoff, Rachel;Matyas, Ferenc;Petersen, Carl C. H.
初级躯体感觉桶皮层处理触觉触须信息，使啮齿动物能够主动感知其周围环境的空间和纹理特征。每个胡须上的吻是单独表示在新皮层的解剖学上可识别的“桶”指定的分隔终止区丘脑皮质轴突的腹后内侧核，提供主要的感觉输入到新皮层。感官信息随后在局部突触连接的新皮层微回路内进行处理，这已经开始进行定量详细的研究。除了这些局部突触微电路，桶皮质的兴奋性锥体神经元还向各种特定的脑区域发送和接收长距离的突触能轴突投射。关于这些长距离连接及其对感觉处理的贡献，我们知道的要少得多。在这里，我们回顾了目前的知识，长距离轴突输入和输出的小鼠初级躯体感觉桶皮层。初级躯体感觉皮层与次级躯体感觉皮层、运动皮层、嗅周皮层和丘脑之间存在明显的相互投射。初级躯体感觉桶皮质也向纹状体、丘脑网状核、齿状回、顶盖前核、上级丘、脑桥、红核和三叉神经脑干脊束核投射。桶状皮层与其他特定皮层和皮层下脑区的这些长距离连接可能在感觉运动整合、感觉知觉和联想学习中起着至关重要的作用。
The primary somatosensory barrel cortex processes tactile vibrissae information, allowing rodents to actively perceive spatial and textural features of their immediate surroundings. Each whisker on the snout is individually represented in the neocortex by an anatomically identifiable 'barrel' specified by the segregated termination zones of thalamocortical axons of the ventroposterior medial nucleus, which provide the primary sensory input to the neocortex. The sensory information is subsequently processed within local synaptically connected neocortical microcircuits, which have begun to be investigated in quantitative detail. In addition to these local synaptic microcircuits, the excitatory pyramidal neurons of the barrel cortex send and receive long-range glutamatergic axonal projections to and from a wide variety of specific brain regions. Much less is known about these long-range connections and their contribution to sensory processing. Here, we review current knowledge of the long-range axonal input and output of the mouse primary somatosensory barrel cortex. Prominent reciprocal projections are found between primary somatosensory cortex and secondary somatosensory cortex, motor cortex, perirhinal cortex and thalamus. Primary somatosensory barrel cortex also projects strongly to striatum, thalamic reticular nucleus, zona incerta, anterior pretectal nucleus, superior colliculus, pons, red nucleus and spinal trigeminal brain stem nuclei. These long-range connections of the barrel cortex with other specific cortical and subcortical brain regions are likely to play a crucial role in sensorimotor integration, sensory perception and associative learning.