Whole genome sequence analysis of Mycobacterium suricattae
Whole genome sequence analysis of Mycobacterium suricattae
复制标题
DOI：
10.1016/j.tube.2015.10.001
复制
发表时间：
2015-12-01
期刊：
影响因子：
3.2
通讯作者：
Warren, Robin Mark
中科院分区：
文献类型：
--
作者：
Dippenaar, Anzaan;Parsons, Sven David Charles;Warren, Robin Mark
结核病发生在各种哺乳动物宿主中，并且由结核分枝杆菌复合体（MTBC）的一系列不同谱系引起。最近描述的成员，分枝杆菌suricattae，导致结核病的猫鼬（Suricata suricatta）在南部非洲和初步的遗传分析表明，这种生物体是密切相关的MTBC病原体岩蹄兔（Procavia capensis），达西杆菌。本文利用全基因组测序的方法对M. suricattae，包括已知的和新的差异区域，SNPs和IS6110插入位点。我们使用全基因组系统发育分析表明，M。suricattae与黑猩猩芽孢杆菌（先前从西非的黑猩猩（Pan troglodytes）中分离出）聚在一起。我们提出了一个非洲分枝杆菌谱系6复合体的进化方案，显示了M。africanum和黑猩猩芽孢杆菌，以及与黑猩猩芽孢杆菌关系密切的M. suricattae，dassie杆菌和孟氏分枝杆菌。(C)2015爱思唯尔有限公司版权所有。
Tuberculosis occurs in various mammalian hosts and is caused by a range of different lineages of the Mycobacterium tuberculosis complex (MTBC). A recently described member, Mycobacterium suricattae, causes tuberculosis in meerkats (Suricata suricatta) in Southern Africa and preliminary genetic analysis showed this organism to be closely related to an MTBC pathogen of rock hyraxes (Procavia capensis), the dassie bacillus. Here we make use of whole genome sequencing to describe the evolution of the genome of M. suricattae, including known and novel regions of difference, SNPs and IS6110 insertion sites. We used genome-wide phylogenetic analysis to show that M. suricattae clusters with the chimpanzee bacillus, previously isolated from a chimpanzee (Pan troglodytes) in West Africa. We propose an evolutionary scenario for the Mycobacterium africanum lineage 6 complex, showing the evolutionary relationship of M. africanum and chimpanzee bacillus, and the closely related members M. suricattae, dassie bacillus and Mycobacterium mungi. (C) 2015 Elsevier Ltd. All rights reserved.