Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions.
Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions.
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在潜在的益生元地球条件下线性二肽形成环状二肽
DOI：
10.3389/fchem.2021.675821
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Guo Y;Ying J;Sun D;Zhang Y;Zheng M;Ding R;Liu Y;Zhao Y
环二肽（DKPs）是肽的前体，也是益生元过程中的手性催化剂。本研究报告了在水溶液下从线性二肽自发获得的含脯氨酸的DKP。显著地，DKP的产率受线性二肽的序列和反应是否含有三偏磷酸的影响。这些发现提供了DKPs可能在生命起源中发挥关键作用的可能性。
Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.