A comparison between muscle function and body composition in anorexia nervosa: the effect of refeeding.
A comparison between muscle function and body composition in anorexia nervosa: the effect of refeeding.
复制标题
神经性厌食症患者肌肉功能和身体成分的比较：重新进食的影响。
DOI：
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发表时间：
1983
影响因子：
7.1
通讯作者：
K. Jeejeebhoy
中科院分区：
文献类型：
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作者：
D. Russell;P. Prendergast;P. Darby;P. Garfinkel;J. Whitwell;K. Jeejeebhoy
对6例重度耗竭的原发性神经性厌食症患者在入院时和口服再喂养时的骨骼肌功能、身体组成（全身总氮和全身总钾）和营养评估的标准参数进行了测量。用电刺激尺神经来评估拇内收肌的功能。入院时，神经性厌食症患者（n = 6）的肌肉功能明显异常，与正常受试者（n = 22）相比，10 Hz时的收缩力明显增加，平均+/- SEM分别为48.0 +/- 3.7%和28.8 +/- 1.2% （p < 0.001）。最大松弛速率减慢，分别为6.6 +/- 0.6%和9.6 +/- 0.2% (p < 0.001)，肌肉疲劳增加，分别为18.6 +/- 5.9%和3.5 +/- 0.8% （p < 0.01）。最初，平均血清白蛋白正常（4.0 +/- 0.1 g/dl），尽管有证据表明体细胞蛋白储存严重消耗，总氮和肌酐高度指数较低。口服再喂养4周内，最大松弛率和肌肉疲劳恢复正常，8周内肌肉功能各项参数恢复正常。在研究期间，全身总氮只增加了13%，仍比预测的正常全身总氮低19.4%，而全身钾增加了32%，体脂增加了46%。肌肉功能的正常化可能与肌肉电解质的恢复有关，而不是体内氮的补充。
Skeletal muscle function, body composition (total body nitrogen and total body potassium) and standard parameters of nutritional assessment were measured in six severely depleted patients with primary anorexia nervosa, both on admission and during oral refeeding. The function of the adductor pollicis muscle was assessed by electrical stimulation of the ulnar nerve. On admission muscle function was markedly abnormal in the patients with anorexia nervosa (n = 6) compared with normal subjects (n = 22), with a significant increase in the force of contraction at 10 Hz, with a mean +/- SEM of 48.0 +/- 3.7% and 28.8 +/- 1.2%, respectively (p less than 0.001). There was slowing of the maximal relaxation rate, 6.6 +/- 0.6% and 9.6 +/- 0.2%, respectively (p less than 0.001) and increased muscle fatigue 18.6 +/- 5.9% and 3.5 +/- 0.8%, respectively (p less than 0.01). Initially, the mean serum albumin was normal (4.0 +/- 0.1 g/dl), although there was evidence of severe depletion of somatic protein stores, with a low total body nitrogen and creatinine-height index. Within 4 wk of oral refeeding, maximal relaxation rate and muscle fatigability were restored to normal, and within 8 wk all parameters of muscle function were normal. During the study total body nitrogen increased by only 13% and was still 19.4% below the predicted normal total body nitrogen, whereas total body potassium increased by 32% and body fat by 46%. Normalization of muscle function may be related to restoration of muscle electrolytes rather than repletion of body nitrogen.