Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits.
Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits.
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DOI：
10.1007/s40473-016-0077-2
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发表时间：
2016-06
影响因子：
1.7
通讯作者：
中科院分区：
文献类型：
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作者：
精神分裂症的特点是广泛的神经认知缺陷，这与更大的残疾、更差的功能结果有关，并且被认为对日常功能的影响大于临床症状。有氧运动（AE）已成为一种潜在的干预措施。本综述探讨了 AE 对精神分裂症患者大脑结构和功能以及神经认知表现的影响。初步证据表明，AE 除了对海马体积减少和皮质变薄发挥神经保护作用外，还可以增加海马体积和皮质厚度。还有证据表明，AE 能够显着增加血清脑源性神经营养因子 (BDNF) 水平，这与神经发生、神经可塑性和认知改善有关。最后，有证据表明 AE 在改善整体认知方面发挥着重要作用，包括提高处理速度、工作记忆和视觉学习。作者讨论了研究结果的含义，并为未来的研究和探究领域提供了建议。
Schizophrenia is characterized by extensive neurocognitive deficits, which are linked to greater disability, poorer functional outcome, and have been suggested to impact daily functioning more than clinical symptoms. Aerobic exercise (AE) has emerged as a potential intervention. This review examines the impact of AE on brain structure and function along with neurocognitive performance in individuals with schizophrenia. Preliminary evidence indicates that AE can increase hippocampal volume and cortical thickness, in addition to exerting a neuroprotective effect against hippocampal volume decrease and cortical thinning. There is also evidence that AE is able to significantly increase serum brain-derived neurotrophic factor (BDNF) levels, which are implicated in neurogenesis, neuroplasticity, and cognitive improvement. Finally, evidence suggests that AE plays a significant role in improving overall cognition, including improvements in processing speed, working memory, and visual learning. The authors discuss the implications of the findings and provide recommendations for future research and areas of inquiry.