HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601).
HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601).
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印度北部人群中的 HLA-DPB1 等位基因和新变体的描述 (DPB1*5601)。
DOI：
10.1111/j.1399-0039.1995.tb02450.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Stastny,P
中科院分区：
文献类型：
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作者：
Rani,R;Fernandez-Viña,MA;Zhang,S;Stastny,P
采用PCR -寡分型技术对51名正常人和93名北印度麻风病患者的HLA - DPB1等位基因进行了研究。杂交模式鉴定出47个等位基因，其中20个等位基因存在于所研究的群体中。DPB1*0401是最常见的等位基因，频率为66.7%，其次是DPB1*0402（21.6%）、DPB1*0201（21.6%）、DPB1*1301（15.7%）和DPB1*0301（13.7%）。除常见等位基因外，低频率还存在DPB1*0101、*1701、*2601、*1001、*1601、*0901、*2901、*1501、*0501、*1401和*3301等位基因。DPB1*2101、DPB1*2801、DPBP3201和DPB1*3501在正常人中未发现，但在麻风患者组中观察到。DPB1*0202、*0601、*0801和*1101在该人群中未检出。对两个具有明显新杂交模式的等位基因进行了分离和测序。获得的核苷酸序列证实了杂交模式。其中一个序列（DPB1 * 4601）证实了最近报道的一个序列。另一种型号的官方编号为DPB1*5601。
HLA‐DPB1 alleles were studied in 51 normal individuals and 93 leprosy patients from North India using a PCR‐oligotyping technique. Hybridization patterns could identify 47 alleles of which 20 were found in the population studied. DPB1*0401 was found to be the most frequent allele with a frequency of 66.7% followed by DPB1*0402 (21.6%), DPB1*0201 (21.6%), DPB1*1301 (15.7%) and DPB1*0301 (13.7%). Besides the common alleles, DPB1*0101, *1701, *2601, *1001, *1601, *0901, *2901, *1501, *0501, *1401, and *3301 were observed at low frequencies. DPB1*2101, DPB1*2801, DPBP3201 and DPB1*3501 were not found in the normal individuals studied but were observed in the group of leprosy patients. DPB1*0202, *0601, *0801 and *1101 were not found in this population. Two alleles with apparent new hybridization patterns were isolated and sequenced. The nucleotide sequences obtained have confirmed the hybridization patterns. One of them (DPB1 * 4601) confirms a sequence recently reported. The other has been given the official designation of DPB1*5601.