Metabolism and health effects of phyto-estrogens
Metabolism and health effects of phyto-estrogens
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植物雌激素的代谢和健康影响
DOI：
10.1080/10408398.2015.1077194
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发表时间：
2017
影响因子：
10.2
通讯作者：
Xie Mingyong
中科院分区：
文献类型：
--
作者：
Nie Qixing;Xing Mengmeng;Hu Jielun;Hu Xiaojuan;Nie Shaoping;Xie Mingyong
植物雌激素是植物源性化合物，可以发挥各种雌激素和抗雌激素作用，由于其对健康有益，包括降低骨质疏松症、心脏病、乳腺癌和更年期症状的风险，通常被用作雌激素替代品的天然替代品。植物雌激素也被认为是内分泌干扰物，因为其结构与人类女性激素 17-β 雌二醇相似。然而，植物雌激素对人类健康是否有益或有害的问题仍不清楚，因为这可能取决于植物雌激素的剂量、形式、水平和服用时间，以及遗传、新陈代谢、肠道生理、年龄、饮食和个人健康状况的影响。鉴于其对人类健康的两个副作用以及全球植物雌激素消费量的迅速增加，有必要澄清这个问题。本综述主要包括植物雌激素的代谢，并权衡支持和反对植物雌激素所声称的健康益处和副作用的证据。
Phyto-estrogens are plant-derived compounds that can exert various estrogenic and anti-estrogenic effects, and are usually used as a natural alternative to estrogen replacement due to their health benefits, including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms. Phyto-estrogens are also considered as endocrine disruptors due to their structure similar to human female hormone 17-β oestradiol. However, the issue of whether phyto-estrogens are beneficial or harmful to human health remains unknown, as this may depend on the dose, form, level and duration of administration of phyto-estrogens, and influence by genetics, metabolism, gut physiology, age, diet, and the health status of individuals. Clarification on this issue is necessary for the sake of their two-side effects on human health and rapidly increasing global consumption of phyto-estrogens. This review mainly includes the metabolism of phyto-estrogens and weighs the evidence for and against the purported health benefits and adverse effects of phyto-estrogens.