Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container
Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container
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DOI：
10.1021/nl901165f
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发表时间：
2009-06-01
期刊：
影响因子：
10.8
通讯作者：
Yan, Hao
中科院分区：
文献类型：
--
作者：
Ke, Yonggang;Sharma, Jaswinder;Yan, Hao
我们描述了一种基于支架DNA折纸的策略来设计和构建内部体积由三角形面封闭的四面体几何形状的三维分子笼。三角形面的每条边的尺寸都类似于54纳米。估计三角形金字塔的总外部体积和内部空腔分别约为1.8 x 10（-23）和1.5 x 10(-23) m(3)。通过凝胶电泳、原子力显微镜、透射电子显微镜和动态光散射技术验证了四面体DNA笼的正确形成。
We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is similar to 54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 x 10(-23) and 1.5 x 10(-23) m(3), respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.