Regulation of the Caulobacter flagellar gene hierarchy; not just for motility.
Regulation of the Caulobacter flagellar gene hierarchy; not just for motility.
复制标题
柄杆菌鞭毛基因等级的调控；
DOI：
10.1046/j.1365-2958.1997.3281691.x
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发表时间：
1997
影响因子：
3.6
通讯作者：
Newton,A
中科院分区：
文献类型：
--
作者：
Wu,J;Newton,A
新月形杆菌鞭毛不仅是一种运动器官，而且是这种不对称分裂细菌分化的关键标志。鞭毛生物合成的一个独特方面是鞭毛基因在细胞周期中的周期性表达，其顺序与基因产物组装到生长的鞭毛中的顺序相对应。这一基因表达程序的实现部分是通过将鞭毛基因组织成四层调控层次结构来实现的，该层次结构在转录和转录后水平控制它们的表达。由于发育程序与不对称细胞分裂周期公司的紧密联系。对鞭毛基因调控和运动性的研究也开始揭示控制细胞周期本身的基本机制。在这里，我们回顾了最近关于鞭毛基因层级调控的工作。新月，并考虑不同于在大肠杆菌和鼠伤寒沙门氏菌中描述的调控机制。
TheCaulobacter crescentusflagellum serves not only as a motility apparatus, but also as a key landmark in the differentiation of this asymmetrically dividing bacterium. A distinctive aspect of flagellum biosynthesis is the periodic expression of the flagellar genes during the cell cycle in a sequence corresponding to the order of gene product assembly into the growing flagellum. This program of gene expression is achieved in part by the organization of flagellar genes into a four‐tiered regulatory hierarchy that controls their expression at both the transcriptional and post‐transcriptional levels. Because of the close interconnection of the developmental program to the asymmetric cell‐division cycle inC. crescentus, studies of flagellar gene regulation and motility have also begun to reveal basic mechanisms responsible for control of the cell cycle itself. Here, we review recent work on regulation of the flagellar gene hierarchy inC. crescentusand consider regulatory mechanisms that are distinct from those described inEscherichia coliandSalmonella typhimurium.