EFFECT OF BODY-SIZE, PONDEROSITY, AND BLOOD-PRESSURE ON LEFT-VENTRICULAR GROWTH IN CHILDREN AND YOUNG-ADULTS IN THE BOGALUSA HEART-STUDY
EFFECT OF BODY-SIZE, PONDEROSITY, AND BLOOD-PRESSURE ON LEFT-VENTRICULAR GROWTH IN CHILDREN AND YOUNG-ADULTS IN THE BOGALUSA HEART-STUDY
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DOI：
10.1161/01.cir.91.9.2400
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发表时间：
1995-05-01
期刊：
影响因子：
37.8
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
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作者：
URBINA, EM;GIDDING, SS;BERENSON, GS
背景 左心室质量（LVM）的测量非常重要，因为左心室质量增加的人患心血管疾病（包括心肌梗死和充血性心力衰竭）的风险也会增加。关于儿童和年轻人获得 LVM 的情况，以及性别、生长、体重超标和血压（BP）对 LVM 变化的相对重要性，目前的纵向数据很有限。在 2 到 3 年的时间里，所有记录的血压水平均保持稳定。重复检查的时间间隔为 4 至 5 年。每次检查时，由经过培训的检查人员使用水银血压计测量 6 次血压。观察结果取平均值，以第四个 Korotkoff 阶段作为舒张压的测量值。此外，还获得了包括身高（HT）、体重（WT）和肱三头肌皮褶厚度（TSF）在内的人体测量数据，并进行了 M 型超声心动图检查。用腓肠肌指数（PI=WT/HT3）来衡量体重与身高的比例。在两个系列中，对 HT（r=.68 至 .76）、WT（r=.73 至 .82）、PI（r=.77 至 .89）、TSF（r=.70 至 .80）、BP（r=.47 至 .60）和 LVM（r=.40 至 .70）的追踪都很强（P＜0.05）。
Background The measurement of left ventricular mass (LVM) is important because individuals with increased LVM are at increased risk for cardiovascular diseases, including myocardial infarction and congestive heart failure. There are limited longitudinal data on the acquisition of LVM in children and young adults and the relative importance of sex, growth, excess body weight, and blood pressure (BP) on change in LVM.Methods and Results The study cohort consisted of a cross section of 160 healthy children and young adults 9 to 22 years of age at first exam in the biracial community of Bogalusa, La. All had stable BP levels recorded over a 2- to 3-year period. Repeated examinations were performed 4 to 5 years apart. At each exam, 6 BPs were obtained with a mercury sphygmomanometer by trained examiners. The mean of the observations was used, with the fourth Korotkoff phase serving as the measure of diastolic BP. Anthropometric data, including height (HT), weight (WT), and triceps skin fold thickness (TSF), were also obtained, and M-mode echocardiograms were performed. Ponderal index (PI=WT/HT3) was used as a measure of weight-for-height. Tracking of HT (r=.68 to .76), WT (r=.73 to .82), PI (r=.77 to.89), TSF (r=.70 to .80), BP (r=.47 to .60), and LVM (r=.40 to .70) was strong in both series (P