Stem cell differentiation: cardiac repair.
Stem cell differentiation: cardiac repair.
复制标题
干细胞分化：心脏修复。
DOI：
10.1159/000112846
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Field,LorenJ
中科院分区：
文献类型：
--
作者：
Rubart,Michael;Field,LorenJ
细胞移植已用于将供体心肌细胞输送至正常和受伤的心脏多年。最近关于多种具有明显心肌生成潜力的干细胞的报道提出了基于细胞移植的心脏病治疗干预的可能性。在这里，我们回顾了临床前研究，证明骨骼肌母细胞、心肌细胞和心肌干细胞的心内移植是可行的。此外，还讨论了骨骼肌成肌细胞和成体干细胞移植治疗心脏病的最新临床研究。
Cellular transplantation has been employed for several years to deliver donor cardiomyocytes to normal and injured hearts. Recent reports of a variety of stem cells with apparent cardiomyogenic potential have raised the possibility of cell transplantation-based therapeutic interventions for heart disease. Here we review the preclinical studies demonstrating that intracardiac transplantation of skeletal myoblasts, cardiomyocytes and cardiomyogenic stem cells is feasible. In addition, recent clinical studies of skeletal myoblast and adult stem cell transplantation for heart disease are discussed.