RELATIONSHIPS BETWEEN PLASMODIUM-FALCIPARUM TRANSMISSION BY VECTOR POPULATIONS AND THE INCIDENCE OF SEVERE DISEASE AT 9 SITES ON THE KENYAN COAST
RELATIONSHIPS BETWEEN PLASMODIUM-FALCIPARUM TRANSMISSION BY VECTOR POPULATIONS AND THE INCIDENCE OF SEVERE DISEASE AT 9 SITES ON THE KENYAN COAST
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DOI：
10.4269/ajtmh.1995.52.201
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发表时间：
1995-03-01
影响因子：
3.3
通讯作者：
BEIER, JC
中科院分区：
文献类型：
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作者：
MBOGO, CNM;SNOW, RW;BEIER, JC
研究了恶性疟原虫的传播与肯尼亚Kilifi区9个地点严重疟疾感染的发病率之间的关系。在一年的时间里，密集的蚊子采样产生了冈比亚按蚊。Funestus，An.Coustani，An.Squamosus、An.Nili和An.法罗人。冈比亚按蚊(Anopheles冈比亚)为优势媒介，占采集按蚊总数的98.4%。总体而言，2868人中有3.5%的人。冈比亚亚种室内采集的261份中，有0.8%含有恶性疟原虫的子孢子。在10个月内检测到传播，高峰期为6月至8月和12月至1月。在9个地点中的8个，昆虫学接种率(EIR)平均每年只有4次感染性叮咬(范围0-18)；对于传播强度最高的地点，每年的EIR为60。严重疟疾感染的发生率为每1,000名儿童(0-4岁)8.6至38.1人，与紧急免疫反应无关。在肯尼亚沿海的这些地点，在媒介人口传播水平很低的情况下，严重疾病的发病率很高。关于非洲病媒控制的传统方法，传播的减少，即使达到标准方法几乎检测不到的水平，也可能不会带来相应的严重疾病发病率的长期减少。
The transmission of Plasmodium falciparum was studied in relation to the incidence of severe malaria infections at nine sites in the Kilifi District in Kenya. Intensive mosquito sampling during a one-year period yielded Anopheles gambiae s.l., An. funestus, An. coustani, An. squamosus, An. nili, and An. pharoensis. Anopheles gambiae s.l. was the predominant vector, comprising 98.4% of the total anophelines collected. Overall, 3.5% of 2,868 An. gambiae s.l. collected indoors and 0.8% of 261 collected outdoors contained P. falciparum sporozoites. Transmission was detected during 10 months, with peak periods from June to August and December to January. In eight of the nine sites, entomologic inoculation rates (EIRs) averaged only four infective bites per year (range 0-18); an annual EIR of 60 was measured for the site with the highest intensity of transmission. The incidence of severe malaria infections, ranging from 8.6 to 38.1 per 1,000 children (0-4 years), was not associated with EIRs. At these sites on the coast of Kenya, a high incidence of severe disease occurs under conditions of very low levels of transmission by vector populations. With respect to conventional approaches for vector control in Africa, decreases in transmission, even to levels barely detectable by standard approaches, may not yield corresponding long-term reductions in the incidence of severe disease.