Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an
Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an
复制标题
淮安市食管癌高发区饮用水及人体尿液中N-亚硝胺分布
DOI：
10.1016/j.chemosphere.2019.06.124
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发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
Lihong Yin
中科院分区：
文献类型：
--
作者：
Chao Zhao;Qiang Lu;Yun Gu;Enchun Pan;Zhongming Sun;Hu Zhang;Jingjing Zhou;Ying Du;Ying Zhang;Yuanmei Feng;Ran Liu;Yuepu Pu;Lihong Yin
江苏淮安地区位于中国东部，是食道癌的高发区。EC的区域异质性表明，潜在致癌物的水平可能在整个环境中有所不同。有人提出，与EC有关的最有可能的致癌物质是一类被称为N-亚硝胺的物质。在本研究中，我们在中国的两个地区，一个EC高发区(淮安)和一个低发区(南京)，检测了饮用水和尿中9种亚硝胺的浓度。在9种目标分析物中，N-亚硝基二正丙胺(NDPA)、N-亚硝基二丁胺(NDBA)、N-亚硝基吡咯烷(NPyr)、N-亚硝基二乙胺(NDEA)和N-亚硝基吗啉(NMOR)在高发区饮用水中浓度较高。高发区居民尿液中NDEA、NDBA、N-亚硝基哌啶(NPip)和N-亚硝基二苯胺(NDPhA)浓度明显升高。这些发现表明，EC高发区的人们暴露在更高水平的亚硝胺中。然而，需要更详细地评估EC发病率与亚硝胺暴露之间的关系。
The Huai'an area in Jiangsu Province of East China is an endemic region of esophageal cancer (EC). The regional heterogeneity of EC suggests that the levels of potential carcinogens might vary throughout the environment. It has been suggested that the most likely carcinogens related to EC are a group known as the N-nitrosamines. In this study, we measured the concentrations of nine nitrosamines in drinking water and human urine in two areas in China, one with a high incidence of EC (Huai'an) and one with a low incidence (Nanjing). Among the nine target analytes, N-nitrosodi-n-propylamine (NDPA), N-nitrosodibutylamine (NDBA), N-nitrosopyrrolidine (NPyr), N-nitrosodiethylamine (NDEA) and N-nitrosomorpholine (NMor) occurred at higher concentrations in drinking water in the high incidence area. Inhabitants from the high incidence area also had urinary excretions with significantly higher concentrations of NDEA, NDBA, N-nitrosopiperidine (NPip) and N-nitrosodiphenylamine (NDPhA). These findings indicated that people in the high EC incidence area were exposed to higher levels of nitrosamines. However, the association between the incidence of EC and nitrosamines exposure will need to be evaluated in more detail.