Anesthetic effects on fictive locomotion in the rat isolated spinal cord.
Anesthetic effects on fictive locomotion in the rat isolated spinal cord.
复制标题
麻醉对大鼠离体脊髓虚拟运动的影响。
DOI：
10.1097/wnr.0b013e32834a20f2
复制
发表时间：
2011
期刊：
影响因子：
1.7
通讯作者：
Satter,Omar
中科院分区：
文献类型：
--
作者：
Jinks,StevenL;Andrada,Jason;Satter,Omar
全身麻醉机制知之甚少。麻醉固定作用发生在脊髓腹角。然而，麻醉剂对腹侧运动网络的影响缺乏详细的分析。我们在NMDA/5-HT诱导或伤害性尾部刺激诱发的新生大鼠离体脊髓虚构运动过程中给予异氟烷、地氟烷或丙泊酚。麻醉剂改变了频率，幅度和规律性的虚构运动的相位滞后的影响不大。在相似浓度下，异氟烷可消除药理学诱导的运动输出与有害刺激诱导的运动输出。丙泊酚通过γ-氨基丁酸A型受体机制消除药理学诱导的虚构运动。麻醉对药理学诱发的虚构运动的影响似乎与临床相关，并支持腹角对运动节律产生的固定作用。
General anesthetic mechanisms are poorly understood. Anesthetic immobilizing effects occur in the spinal ventral horn. However, a detailed analysis of anesthetic effects on ventral motor networks is lacking. We delivered isoflurane, desflurane, or propofol during NMDA/5-HT-induced, or noxious tail stimulus-evoked, fictive locomotion in neonatal rat isolated spinal cords. Anesthetics changed the frequency, amplitude, and regularity of fictive locomotion with little effect on phase-lag. Isoflurane abolished pharmacologically-induced versus noxious stimulus-induced motor output at similar concentrations. Propofol abolished pharmacologically-induced fictive locomotion through a γ-aminobutyric acid type A-receptor mechanism. Anesthetic effects on pharmacologically-elicted fictive locomotion appear clinically-relevant, and support a ventral horn immobilizing effect on locomotor rhythm generation.